| Literature DB >> 14595552 |
Margaret A Pericak-Vance1, Jackie B Rimmler, Jonathan L Haines, Melissa E Garcia, Jorge R Oksenberg, Lisa F Barcellos, Robin Lincoln, Stephen L Hauser, Isabelle Cournu-Rebeix, Ariele Azoulay-Cayla, Olivier Lyon-Caen, Bertrand Fontaine, Emmanuelle Duhamel, Helene Coppin, David Brassat, Marie-Paule Roth, Michel Clanet, Mehdi Alizadeh, Jacqueline Yaouanq, Erwann Quelvennec, Gilbert Semana, Gilles Edan, Marie-Claude Babron, Emmanuelle Genin, Francoise Clerget-Darpoux.
Abstract
Multiple sclerosis (MS) is a demyelinating autoimmune disease with a strong yet complex genetic component. To date only the HLA-DR locus, and specifically the HLA-DR15 allele, has been identified and confirmed as influencing the risk of developing MS. Genomic screens on several datasets have been performed and have identified several chromosomal regions with interesting results, but none have yet been confirmed. We tested seven of the most-promising regions (on chromosomes 1p, 2p, 3p, 3q, 5q, 19q, and Xp) identified from several genomic screens in a dataset of 98 multiplex MS families from the United States and 90 multiplex MS families from France. The results did not confirm linkage to 2p, 3q, 5q, or Xp in the overall dataset, or in subsets defined by geographic origin or HLA-DR15 status. Regions on 1p34, 3p14, and 19q13 produced lod scores >0.90 in at least one subset of the data, suggesting that these regions should be examined in more detail.Entities:
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Year: 2003 PMID： 14595552 DOI： 10.1007/s10048-003-0163-y
Source DB: PubMed Journal: Neurogenetics ISSN： 1364-6745 Impact factor: 2.660