Literature DB >> 11477475

A genome screen for multiple sclerosis in Italian families.

S Broadley1, S Sawcer, S D'Alfonso, A Hensiek, F Coraddu, J Gray, R Roxburgh, D Clayton, C Buttinelli, A Quattrone, M Trojano, L Massacesi, A Compston.   

Abstract

We have screened the whole genome for linkage in 40 Italian multiplex families with multiple sclerosis using 322 markers. The GENEHUNTER-PLUS program was used to analyse these data and revealed eight regions of potential linkage where the lod score exceeds the nominal 5% significance level (0.7). No region of linkage with genome-wide significance was identified and none of the markers showed evidence of statistically significant transmission disequilibrium. Overall these results have refined the linkage data relating to this disease in Italians modestly supporting some previously identified areas of interest and helping to exclude others.

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Year:  2001        PMID： 11477475     DOI： 10.1038/sj.gene.6363758

Source DB:  PubMed          Journal:  Genes Immun        ISSN： 1466-4879            Impact factor:   2.676


  14 in total

Review 1.  Genetic analysis of multiple sclerosis.

Authors:  Alastair Compston; Stephen Sawcer
Journal:  Curr Neurol Neurosci Rep       Date:  2002-05       Impact factor: 5.081

2.  A high-density screen for linkage in multiple sclerosis.

Authors:  Stephen Sawcer; Maria Ban; Mel Maranian; Tai Wai Yeo; Alastair Compston; Andrew Kirby; Mark J Daly; Philip L De Jager; Emily Walsh; Eric S Lander; John D Rioux; David A Hafler; Adrian Ivinson; Jacqueline Rimmler; Simon G Gregory; Silke Schmidt; Margaret A Pericak-Vance; Eva Akesson; Jan Hillert; Pameli Datta; Annette Oturai; Lars P Ryder; Hanne F Harbo; Anne Spurkland; Kjell-Morten Myhr; Mikko Laaksonen; David Booth; Robert Heard; Graeme Stewart; Robin Lincoln; Lisa F Barcellos; Stephen L Hauser; Jorge R Oksenberg; Shannon J Kenealy; Jonathan L Haines
Journal:  Am J Hum Genet       Date:  2005-07-29       Impact factor: 11.025

3.  Eae19, a new locus on rat chromosome 15 regulating experimental autoimmune encephalomyelitis.

Authors:  Jian Rong Sheng; Maja Jagodic; Ingrid Dahlman; Kristina Becanovic; Rita Nohra; Monica Marta; Ellen Iacobaeus; Tomas Olsson; Erik Wallström
Journal:  Genetics       Date:  2005-02-16       Impact factor: 4.562

4.  The genetic aspects of multiple sclerosis.

Authors:  Stephen Sawcer
Journal:  Ann Indian Acad Neurol       Date:  2009-10       Impact factor: 1.383

5.  A second-generation genomic screen for multiple sclerosis.

Authors:  S J Kenealy; M-C Babron; Y Bradford; N Schnetz-Boutaud; J L Haines; J B Rimmler; S Schmidt; M A Pericak-Vance; L F Barcellos; R R Lincoln; J R Oksenberg; S L Hauser; M Clanet; D Brassat; G Edan; J Yaouanq; G Semana; I Cournu-Rebeix; O Lyon-Caen; B Fontaine
Journal:  Am J Hum Genet       Date:  2004-10-19       Impact factor: 11.025

6.  Investigation of seven proposed regions of linkage in multiple sclerosis: an American and French collaborative study.

Authors:  Margaret A Pericak-Vance; Jackie B Rimmler; Jonathan L Haines; Melissa E Garcia; Jorge R Oksenberg; Lisa F Barcellos; Robin Lincoln; Stephen L Hauser; Isabelle Cournu-Rebeix; Ariele Azoulay-Cayla; Olivier Lyon-Caen; Bertrand Fontaine; Emmanuelle Duhamel; Helene Coppin; David Brassat; Marie-Paule Roth; Michel Clanet; Mehdi Alizadeh; Jacqueline Yaouanq; Erwann Quelvennec; Gilbert Semana; Gilles Edan; Marie-Claude Babron; Emmanuelle Genin; Francoise Clerget-Darpoux
Journal:  Neurogenetics       Date:  2003-11-01       Impact factor: 2.660

7.  Meta-analysis of genome-wide linkage studies across autoimmune diseases.

Authors:  Paola Forabosco; Emmanuelle Bouzigon; Mandy Y Ng; Jane Hermanowski; Sheila A Fisher; Lindsey A Criswell; Cathryn M Lewis
Journal:  Eur J Hum Genet       Date:  2008-09-10       Impact factor: 4.246

8.  A genome-wide scan in forty large pedigrees with multiple sclerosis.

Authors:  Cristen J Willer; David A Dyment; Stacey Cherny; Sreeram V Ramagopalan; Blanca M Herrera; Katie M E Morrison; A Dessa Sadovnick; Neil J Risch; George C Ebers
Journal:  J Hum Genet       Date:  2007-11-15       Impact factor: 3.172

9.  The role of hereditary spastic paraplegia related genes in multiple sclerosis. A study of disease susceptibility and clinical outcome.

Authors:  G C DeLuca; S V Ramagopalan; M Z Cader; D A Dyment; B M Herrera; S Orton; A Degenhardt; M Pugliatti; A D Sadovnick; S Sotgiu; G C Ebers
Journal:  J Neurol       Date:  2007-04-10       Impact factor: 4.849

10.  Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.

Authors:  J L McCauley; R L Zuvich; Y Bradford; S J Kenealy; N Schnetz-Boutaud; S G Gregory; S L Hauser; J R Oksenberg; D P Mortlock; M A Pericak-Vance; J L Haines
Journal:  Genes Immun       Date:  2009-07-23       Impact factor: 2.676
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