Literature DB >> 14592885

Analysis of CD4+CD25+ cell population in the thymus from myasthenia gravis patients.

A Balandina1, A Saoudi, P Dartevelle, S Berrih-Aknin.   

Abstract

The present study is aimed at exploring the regulatory CD4(+)CD25(+) T cells in the thymus from myasthenia gravis (MG) patients. In early-onset MG, the thymus is hyperplastic and contains autoreactive activated T cells. Preliminary studies indicate that these CD4(+)CD25(+) cells include activated autoreactive T cells. Studies to characterize the phenotype and suppressive capacity of these cells will be discussed.

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Year:  2003        PMID： 14592885      PMCID： PMC1847366          DOI： 10.1196/annals.1254.030

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  4 in total

1.  Thymic B cells from myasthenia gravis patients are activated B cells. Phenotypic and functional analysis.

Authors:  C Leprince; S Cohen-Kaminsky; S Berrih-Aknin; B Vernet-Der Garabedian; D Treton; P Galanaud; Y Richard
Journal:  J Immunol       Date:  1990-10-01       Impact factor: 5.422

2.  Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro.

Authors:  L A Stephens; C Mottet; D Mason; F Powrie
Journal:  Eur J Immunol       Date:  2001-04       Impact factor: 5.532

3.  Thymocyte Fas expression is dysregulated in myasthenia gravis patients with anti-acetylcholine receptor antibody.

Authors:  N Moulian; J Bidault; F Truffault; A M Yamamoto; P Levasseur; S Berrih-Aknin
Journal:  Blood       Date:  1997-05-01       Impact factor: 22.113

Review 4.  CD4+ CD25+ suppressor T cells: more questions than answers.

Authors:  Ethan M Shevach
Journal:  Nat Rev Immunol       Date:  2002-06       Impact factor: 53.106
  4 in total
  6 in total

1.  Circulating and thymic CD4 CD25 T regulatory cells in myasthenia gravis: effect of immunosuppressive treatment.

Authors:  Andrea Fattorossi; Alessandra Battaglia; Alexia Buzzonetti; Francesca Ciaraffa; Giovanni Scambia; Amelia Evoli
Journal:  Immunology       Date:  2005-09       Impact factor: 7.397

2.  CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis.

Authors:  Clare M Baecher-Allan; Cristina M Costantino; Gregory L Cvetanovich; Charles W Ashley; Gaëlle Beriou; Margarita Dominguez-Villar; David A Hafler
Journal:  J Immunol       Date:  2011-02-07       Impact factor: 5.422

Review 3.  Multiple sclerosis and regulatory T cells.

Authors:  Cristina Maria Costantino; Clare Baecher-Allan; David A Hafler
Journal:  J Clin Immunol       Date:  2008-09-02       Impact factor: 8.317

4.  Decreased 4-1BB expression on CD4+CD25 high regulatory T cells in peripheral blood of patients with multiple sclerosis.

Authors:  G-Z Liu; A C Gomes; L-B Fang; X-G Gao; P Hjelmstrom
Journal:  Clin Exp Immunol       Date:  2008-08-22       Impact factor: 4.330

Review 5.  Human regulatory T cells and autoimmunity.

Authors:  Cristina M Costantino; Clare M Baecher-Allan; David A Hafler
Journal:  Eur J Immunol       Date:  2008-04       Impact factor: 5.532

6.  Paracrine co-delivery of TGF-β and IL-2 using CD4-targeted nanoparticles for induction and maintenance of regulatory T cells.

Authors:  Michael D McHugh; Jason Park; Ross Uhrich; Wenda Gao; David A Horwitz; Tarek M Fahmy
Journal:  Biomaterials       Date:  2015-05-15       Impact factor: 15.304
  6 in total

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