| Literature DB >> 14592520 |
Paul D Greenspan1, Kirk L Clark, Scott D Cowen, Leslie W McQuire, Ruben A Tommasi, David L Farley, Elizabeth Quadros, David E Coppa, Zengming Du, Zheng Fang, Huanghai Zhou, John Doughty, Karen T Toscano, Andrew M Wigg, Siyuan Zhou.
Abstract
To improve the pharmacokinetics of a previously reported series of dipeptidyl nitrile cathepsin B inhibitors, the P(2)-P(3) amide group was replaced with an arylamine. Further optimization of this template resulted in highly potent and selective inhibitors with excellent oral availability.Entities:
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Year: 2003 PMID： 14592520 DOI： 10.1016/j.bmcl.2003.08.006
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823