Literature DB >> 14592494

Pyridone-containing farnesyltransferase inhibitors: synthesis and biological evaluation.

Lisa A Hasvold1, Weibo Wang, Stephen L Gwaltney, Todd W Rockway, Lissa T J Nelson, Robert A Mantei, Stephen A Fakhoury, Gerard M Sullivan, Qun Li, Nan-Horng Lin, Le Wang, Haiying Zhang, Jerome Cohen, Wen-Zhen Gu, Kennan Marsh, Joy Bauch, Saul Rosenberg, Hing L Sham.   

Abstract

Farnesyltransferase inhibitors (FTIs) have been developed as potential anti-cancer agents due to their efficacy in blocking malignant growth in a variety of murine models of human tumors. To that end, we have developed a series of pyridone farnesyltransferase inhibitors with potent in vitro and cellular activity. The synthesis, SAR and biological properties of these compounds will be discussed.

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Year:  2003        PMID： 14592494     DOI： 10.1016/j.bmcl.2003.08.058

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  6-Amino-4-(4-chloro-phen-yl)-2-oxo-1,2-dihydro-pyridine-3,5-dicarbonitrile ethanol solvate.

Authors:  Runhong Jia; Shujiang Tu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-07-23

2.  Imidazole-containing farnesyltransferase inhibitors: 3D quantitative structure-activity relationships and molecular docking.

Authors:  Aihua Xie; Srinivas Odde; Sivaprakasam Prasanna; Robert J Doerksen
Journal:  J Comput Aided Mol Des       Date:  2009-05-29       Impact factor: 3.686

3.  Design, Synthesis, and Antimicrobial Evaluation of a New Series of N-Sulfonamide 2-Pyridones as Dual Inhibitors of DHPS and DHFR Enzymes.

Authors:  Rasha A Azzam; Rasha E Elsayed; Galal H Elgemeie
Journal:  ACS Omega       Date:  2020-04-28

4.  Cobalt(iii)-catalyzed site-selective C-H amidation of pyridones and isoquinolones.

Authors:  Feng Gao; Xu Han; Chunpu Li; Lingjun Liu; Zhanqing Cong; Hong Liu
Journal:  RSC Adv       Date:  2018-09-21       Impact factor: 3.361

5.  Novel 2-Hydroselenonicotinonitriles and Selenopheno[2, 3-b]pyridines: Efficient Synthesis, Molecular Docking-DFT Modeling, and Antimicrobial Assessment.

Authors:  Magda H Abdellattif; Adel A H Abdel-Rahman; Mohamed Mohamed Helmy Arief; Samar M Mouneir; Amena Ali; Mostafa A Hussien; Rawda M Okasha; Tarek H Afifi; Mohamed Hagar
Journal:  Front Chem       Date:  2021-05-10       Impact factor: 5.221

6.  Rhodium(i)-catalyzed C6-selective C-H alkenylation and polyenylation of 2-pyridones with alkenyl and conjugated polyenyl carboxylic acids.

Authors:  Haoqiang Zhao; Xin Xu; Zhenli Luo; Lei Cao; Bohan Li; Huanrong Li; Lijin Xu; Qinghua Fan; Patrick J Walsh
Journal:  Chem Sci       Date:  2019-09-09       Impact factor: 9.825
  6 in total

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