| Literature DB >> 1459241 |
K M Dolman1, B A van de Wiel, C M Kam, J J Abbink, C E Hack, A Sonnenberg, J C Powers, A E von dem Borne, R Goldschmeding.
Abstract
Physiological inhibitors were tested for their in vitro interaction with neutrophil proteinase 3 (PR3). The major plasma proteinase inhibitor of PR3 is alpha 1AT. We have developed a radioimmunoassay (RIA) for quantitative detection of PR3-alpha 1AT complexes formed in vivo in inflammatory exudates such as synovial fluid and plasma from patients with sepsis. Levels of PR3-alpha 1AT complexes correlated significantly with levels of human neutrophil elastase (HNE)-alpha 1AT complexes. Thus, in vivo alpha 1AT not only protects against excessive HNE activity, but also against excessive PR3 activity.Entities:
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Year: 1992 PMID： 1459241 DOI： 10.1016/0014-5793(92)80955-g
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124