OBJECTIVE: The purpose of this study was to examine the risk of infertility that is associated with paternal age, because this factor rarely has been investigated, whereas maternal age of >or=35 years is a well-known risk factor. STUDY DESIGN: This large, retrospective, population-based sample included 6188 European women (from Denmark, Italy, Spain, Germany) aged 25 to 44 years who were selected randomly from census registers in 1991 through 1993. RESULTS: Among couples composed of a woman aged 35 to 39 years, risks were significantly higher when paternal age was >or=40 years than when paternal age was <40 years, with an adjusted odds ratio of 2.21 (95% CI, 1.13, 4.33) for delay in pregnancy onset (failure to conceive within 12 months) and of 3.02 (95% CI, 1.56, 5.85) for difficulties in having a baby (failure to conceive within 12 months or pregnancy not resulting in a live birth). CONCLUSION: Like maternal age of >or=35 years, paternal age of >or=40 years should be considered to be a key risk factor for infertility.
RCT Entities:
OBJECTIVE: The purpose of this study was to examine the risk of infertility that is associated with paternal age, because this factor rarely has been investigated, whereas maternal age of >or=35 years is a well-known risk factor. STUDY DESIGN: This large, retrospective, population-based sample included 6188 European women (from Denmark, Italy, Spain, Germany) aged 25 to 44 years who were selected randomly from census registers in 1991 through 1993. RESULTS: Among couples composed of a woman aged 35 to 39 years, risks were significantly higher when paternal age was >or=40 years than when paternal age was <40 years, with an adjusted odds ratio of 2.21 (95% CI, 1.13, 4.33) for delay in pregnancy onset (failure to conceive within 12 months) and of 3.02 (95% CI, 1.56, 5.85) for difficulties in having a baby (failure to conceive within 12 months or pregnancy not resulting in a live birth). CONCLUSION: Like maternal age of >or=35 years, paternal age of >or=40 years should be considered to be a key risk factor for infertility.
Authors: Sara Darbandi; Mahsa Darbandi; Hamid Reza Khorram Khorshid; Mohammad Reza Sadeghi; Mahnaz Heidari; Ghazaleh Cheshmi; Mohammad Mehdi Akhondi Journal: Turk J Urol Date: 2019-02-05
Authors: Brian W Whitcomb; Renée Turzanski-Fortner; Kevin S Richter; Simon Kipersztok; Robert J Stillman; Michael J Levy; Eric D Levens Journal: Fertil Steril Date: 2010-07-21 Impact factor: 7.329
Authors: Jason R Kovac; Josephine Addai; Ryan P Smith; Robert M Coward; Dolores J Lamb; Larry I Lipshultz Journal: Asian J Androl Date: 2013-08-05 Impact factor: 3.285