Literature DB >> 14585349

Signal transduction: putting translation before transcription.

George C Prendergast1.   

Abstract

A recent microarray-based study shows that Ras/Akt signaling rapidly alters the pattern of existing mRNAs that are recruited to polysomes. This response precedes the effects of transcription on total cellular RNA, suggesting that the primary effect of Ras/Akt signaling on gene expression may occur mainly at the level of translation.

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Year:  2003        PMID: 14585349     DOI: 10.1016/s1535-6108(03)00247-2

Source DB:  PubMed          Journal:  Cancer Cell        ISSN: 1535-6108            Impact factor:   31.743


  4 in total

1.  High-throughput polyribosome fractionation.

Authors:  Yipeng Wang; Steven Ringquist; Ann H Cho; Gaelle Rondeau; John Welsh
Journal:  Nucleic Acids Res       Date:  2004-06-01       Impact factor: 16.971

Review 2.  Cytoplasmatic post-transcriptional regulation and intracellular signalling.

Authors:  Per Sunnerhagen
Journal:  Mol Genet Genomics       Date:  2007-03-01       Impact factor: 3.291

3.  Identification of actively translated mRNA transcripts in a rat model of early-stage colon carcinogenesis.

Authors:  Laurie A Davidson; Naisyin Wang; Ivan Ivanov; Jennifer Goldsby; Joanne R Lupton; Robert S Chapkin
Journal:  Cancer Prev Res (Phila)       Date:  2009-10-20

4.  Fission yeast mitogen-activated protein kinase Sty1 interacts with translation factors.

Authors:  Eva Asp; Daniel Nilsson; Per Sunnerhagen
Journal:  Eukaryot Cell       Date:  2007-12-07
  4 in total

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