| Literature DB >> 14583394 |
Eiji Shimizu1, Kenji Hashimoto, Hiroyuki Watanabe, Naoya Komatsu, Naoe Okamura, Kaori Koike, Naoyuki Shinoda, Michiko Nakazato, Chikara Kumakiri, Sin-ichi Okada, Masaomi Iyo.
Abstract
Our previous study showed that serum brain-derived neurotrophic factor (BDNF) was significantly decreased in the antidepressant-naive patients with major depressive disorders. However, it was still unclear whether serum BDNF level was altered in drug-naive patients with schizophrenia. Using ELISA, we measured serum BDNF levels in antipsychotic-naive (n=15) and medicated (n=25) patients with schizophrenia, and in age- and sex-matched normal controls (n=40). There were no significant differences in serum BDNF levels among antipsychotic-naive (n=15) and medicated (n=25) patients and normal controls (n=40). Possible factors such as duration of illness, age of onset, Brief Psychiatric Rating Scale scores, and chlorpromazine equivalent dosages of antipsychotics did not reveal any significant correlations with BDNF levels. Our results do not support the view that serum BDNF levels are associated with schizophrenia.Entities:
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Year: 2003 PMID： 14583394 DOI： 10.1016/j.neulet.2003.08.004
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046