| Literature DB >> 14575649 |
Caterina Guiot1, Piero Giorgio Degiorgis, Pier Paolo Delsanto, Pietro Gabriele, Thomas S Deisboeck.
Abstract
A general model for the ontogenetic growth of living organisms has been recently proposed. Here we investigate the extension of this model to the growth of solid malignant tumors. A variety of in vitro and in vivo data are analysed and compared with the prediction of a "universal" law, relating properly rescaled tumor masses and tumor growth times. The results support the notion that tumor growth follows such a universal law. Several important implications of this finding are discussed, including its relevance for tumor metastasis and recurrence, cell turnover rates, angiogenesis and invasion.Entities:
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Year: 2003 PMID: 14575649 DOI: 10.1016/s0022-5193(03)00221-2
Source DB: PubMed Journal: J Theor Biol ISSN: 0022-5193 Impact factor: 2.691