Literature DB >> 14573693

Helicobacter pylori cag pathogenicity island is associated with reduced expression of interleukin-4 (IL-4) mRNA and modulation of the IL-4delta2 mRNA isoform in human gastric mucosa.

Barbara Orsini1, Barbara Ottanelli, Amedeo Amedei, Elisabetta Surrenti, Marco Capanni, Gianfranco Del Prete, Andrea Amorosi, Stefano Milani, Mario Milco D'Elios, Calogero Surrenti.   

Abstract

Interleukin-4 (IL-4) and IL-4delta2 mRNA gastric expression was evaluated in healthy subjects and patients who did not have ulcers but were infected with Helicobacter pylori with or without the cag pathogenicity island (cag PAI). IL-4 mRNA was physiologically expressed by gastric epithelium and negatively influenced by H. pylori. Also, nonepithelial cells in the lamina propria of H. pylori-infected patients expressed IL-4 mRNA, whereas IL-4delta2 mRNA was found only in cag PAI-negative patients. Thus, gastric IL-4 takes part in the local immune response to H. pylori.

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Year:  2003        PMID： 14573693      PMCID： PMC219570          DOI： 10.1128/IAI.71.11.6664-6667.2003

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  25 in total

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