Literature DB >> 10334982

Helicobacter pylori virulence and genetic geography.

A Covacci1, J L Telford, G Del Giudice, J Parsonnet, R Rappuoli.   

Abstract

Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence. The infection is now treated with antibiotics, and vaccines are in preparation. The geographic distribution suggests coevolution of man and Helicobacter pylori.

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Year:  1999        PMID： 10334982     DOI： 10.1126/science.284.5418.1328

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  331 in total

Review 1.  Macrolide resistance conferred by base substitutions in 23S rRNA.

Authors:  B Vester; S Douthwaite
Journal:  Antimicrob Agents Chemother       Date:  2001-01       Impact factor: 5.191

Review 2.  Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.

Authors:  P J Christie
Journal:  Mol Microbiol       Date:  2001-04       Impact factor: 3.501

Review 3.  The bases of crown gall tumorigenesis.

Authors:  J Zhu; P M Oger; B Schrammeijer; P J Hooykaas; S K Farrand; S C Winans
Journal:  J Bacteriol       Date:  2000-07       Impact factor: 3.490

4.  Cell specificity of Helicobacter pylori cytotoxin is determined by a short region in the polymorphic midregion.

Authors:  X Ji; T Fernandez; D Burroni; C Pagliaccia; J C Atherton; J M Reyrat; R Rappuoli; J L Telford
Journal:  Infect Immun       Date:  2000-06       Impact factor: 3.441

5.  The six functions of Agrobacterium VirE2.

Authors:  D V Ward; P C Zambryski
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-16       Impact factor: 11.205

6.  Genes for the type IV secretion system in an intracellular symbiont, Wolbachia, a causative agent of various sexual alterations in arthropods.

Authors:  S Masui; T Sasaki; H Ishikawa
Journal:  J Bacteriol       Date:  2000-11       Impact factor: 3.490

Review 7.  Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.

Authors:  P J Christie; J P Vogel
Journal:  Trends Microbiol       Date:  2000-08       Impact factor: 17.079

8.  Molecular mechanisms of H. pylori associated gastric carcinogenesis.

Authors:  Zun-Wu Zhang; Michael JG Farthing
Journal:  World J Gastroenterol       Date:  1999-10       Impact factor: 5.742

9.  Helicobacter pylori uses motility for initial colonization and to attain robust infection.

Authors:  Karen M Ottemann; Andrew C Lowenthal
Journal:  Infect Immun       Date:  2002-04       Impact factor: 3.441

10.  Host cytokine responses to Helicobacter pylori: an important determinant of clinical outcome.

Authors:  B M Ryan; G Murphy; C A O'Morain
Journal:  Ir J Med Sci       Date:  2001 Apr-Jun       Impact factor: 1.568
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