Literature DB >> 1457351

Pixel-to-pixel correlation between images of absolute ATP concentrations and blood flow in tumours.

S Walenta1, M Dellian, A E Goetz, G E Kuhnle, W Mueller-Klieser.   

Abstract

Iodo(14C-)antipyrine autoradiography and imaging bioluminescence have been combined to obtain pixel-to-pixel correlations between absolute values for local blood flow and ATP concentrations at a microscopical level within designated areas in hamster melanomas. Positive pixel-to-pixel correlations were obtained in 4 of 6 tumours. Both flow and ATP values were less in mostly necrotic than in mostly viable tumour regions. The data provide evidence for the energetic state of cancer cells being strongly influenced by the efficiency of tumour microcirculation in several but not in all malignancies investigated.

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Year:  1992        PMID： 1457351      PMCID： PMC1978060          DOI： 10.1038/bjc.1992.417

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  15 in total

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5.  ATP concentrations in multicellular tumor spheroids assessed by single photon imaging and quantitative bioluminescence.

Authors:  S Walenta; J Dötsch; W Mueller-Klieser
Journal:  Eur J Cell Biol       Date:  1990-08       Impact factor: 4.492

6.  Correlations between 31P-NMR spectroscopy and tissue O2 tension measurements in a murine fibrosarcoma.

Authors:  P Vaupel; P Okunieff; F Kallinowski; L J Neuringer
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7.  Measurement of local cerebral blood flow with iodo [14C] antipyrine.

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8.  Measurement of blood flow, oxygen utilisation, oxygen extraction ratio, and fractional blood volume in human brain tumours and surrounding oedematous tissue.

Authors:  A A Lammertsma; R J Wise; T C Cox; D G Thomas; T Jones
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9.  Assessment of tumor energy and oxygenation status by bioluminescence, nuclear magnetic resonance spectroscopy, and cryospectrophotometry.

Authors:  W Mueller-Klieser; C Schaefer; S Walenta; E K Rofstad; B M Fenton; R M Sutherland
Journal:  Cancer Res       Date:  1990-03-15       Impact factor: 12.701

Review 10.  Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

Authors:  P Vaupel; F Kallinowski; P Okunieff
Journal:  Cancer Res       Date:  1989-12-01       Impact factor: 12.701
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  11 in total

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Review 3.  Purinergic signalling and cancer.

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Review 5.  Is there a critical tissue oxygen tension for bioenergetic status and cellular pH regulation in solid tumors?

Authors:  P Vaupel
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6.  Mapping and quantification of biomolecules in tumor biopsies using bioluminescence.

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7.  A bioimage informatics based reconstruction of breast tumor microvasculature with computational blood flow predictions.

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8.  Stable bioenergetic status despite substantial changes in blood flow and tissue oxygenation in a rat tumour.

Authors:  P Vaupel; D K Kelleher; T Engel
Journal:  Br J Cancer       Date:  1994-01       Impact factor: 7.640

9.  Metabolic imaging in tumours by means of bioluminescence.

Authors:  P Tamulevicius; C Streffer
Journal:  Br J Cancer       Date:  1995-11       Impact factor: 7.640

10.  Variation of growth rate of a rat tumour during a light-dark cycle: correlation with circadian fluctuations in tumour blood flow.

Authors:  K Hori; Q H Zhang; H C Li; S Saito
Journal:  Br J Cancer       Date:  1995-06       Impact factor: 7.640
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