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Literature DB >> 14567963

Recent progress in the development of assays suited for histone deacetylase inhibitor screening.

Dennis Wegener¹, Christian Hildmann, Andreas Schwienhorst.

Abstract

Histone deacetylase (HDAC) inhibitors have an unprecedented potential to occupy a major position in the future market of anticancer agents. However, progress in the development of these new chemotherapeutics is largely dependent on the existence of bioassays well-suited for inhibitor screening. Herein, we summarize recent developments in HDAC assay technology and, particularly, discuss different assay types with respect to their suitability for high-throughput screening programs.

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Year: 2003 PMID： 14567963 DOI： 10.1016/j.ymgme.2003.08.008

Source DB: PubMed Journal: Mol Genet Metab ISSN： 1096-7192 Impact factor: 4.797

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Cited

8 in total

1. Coumarin-suberoylanilide hydroxamic acid as a fluorescent probe for determining binding affinities and off-rates of histone deacetylase inhibitors.

Authors: Raushan K Singh; Tanmay Mandal; Narayanaganesh Balasubramanian; Gregory Cook; D K Srivastava
Journal: Anal Biochem Date: 2010-09-22 Impact factor: 3.365

2. An active site tyrosine residue is essential for amidohydrolase but not for esterase activity of a class 2 histone deacetylase-like bacterial enzyme.

Authors: Kristin Moreth; Daniel Riester; Christian Hildmann; René Hempel; Dennis Wegener; Andreas Schober; Andreas Schwienhorst
Journal: Biochem J Date: 2007-02-01 Impact factor: 3.857

3. Comparative studies of thiol-sensitive fluorogenic probes for HAT assays.

Authors: Tielong Gao; Chao Yang; Yujun George Zheng
Journal: Anal Bioanal Chem Date: 2012-11-09 Impact factor: 4.142

4. Differential regulation of connective tissue growth factor in renal cells by histone deacetylase inhibitors.

Authors: Claudiu Komorowsky; Matthias Ocker; Margarete Goppelt-Struebe
Journal: J Cell Mol Med Date: 2009-08 Impact factor: 5.295

Review 5. HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases.

Authors: Elizabeth E Hull; McKale R Montgomery; Kathryn J Leyva
Journal: Biomed Res Int Date: 2016-07-31 Impact factor: 3.411

Recent progress in the development of assays suited for histone deacetylase inhibitor screening.

1. Coumarin-suberoylanilide hydroxamic acid as a fluorescent probe for determining binding affinities and off-rates of histone deacetylase inhibitors.

2. An active site tyrosine residue is essential for amidohydrolase but not for esterase activity of a class 2 histone deacetylase-like bacterial enzyme.

3. Comparative studies of thiol-sensitive fluorogenic probes for HAT assays.

4. Differential regulation of connective tissue growth factor in renal cells by histone deacetylase inhibitors.

Review 5. HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases.

6. Improved mass spectrometry-based activity assay reveals oxidative and metabolic stress as sirtuin-1 regulators.

7. The activity of HDAC8 depends on local and distal sequences of its peptide substrates.

8. In vitro Enzymatic Assays of Histone Decrotonylation on Recombinant Histones.