Literature DB >> 1456776

Oxidative changes in brain of aniline-exposed rats.

P Kakkar1, S Awasthi, P N Viswanathan.   

Abstract

Oxidative stress in rat cerebellum, cortex and brain stem after a short-term high-dose exposure to aniline vapors under conditions akin to those after major chemical accidents, was studied. Significant increases in superoxide dismutase isozyme activities and formation of thiobarbituric acid reactive material along with depletion of ascorbic acid and non-protein sulfhydryl content suggest impairment of antioxidant defenses 24 h after single exposure to 15,302 ppm aniline vapors for 10 min.

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Year:  1992        PMID: 1456776     DOI: 10.1007/bf00216238

Source DB:  PubMed          Journal:  Arch Environ Contam Toxicol        ISSN: 0090-4341            Impact factor:   2.804


  23 in total

1.  Ascorbic acid in aromatic hydroxylation. I. A model system for aromatic hydroxylation.

Authors:  S UDENFRIEND; C T CLARK; J AXELROD; B B BRODIE
Journal:  J Biol Chem       Date:  1954-06       Impact factor: 5.157

2.  Microsomal lipid peroxidation: the role of NADPH--cytochrome P450 reductase and cytochrome P450.

Authors:  A Sevanian; K Nordenbrand; E Kim; L Ernster; P Hochstein
Journal:  Free Radic Biol Med       Date:  1990       Impact factor: 7.376

3.  Induction of superoxide dismutase isozymes in rabbit lung due to aniline exposure.

Authors:  P Kakkar; P N Viswanathan
Journal:  J Appl Toxicol       Date:  1987-02       Impact factor: 3.446

4.  Evidence for biochemically different types of vesicles in the hepatic microsomal fraction.

Authors:  Y Imai; A Ito; R Sato
Journal:  J Biochem       Date:  1966-10       Impact factor: 3.387

5.  Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent.

Authors:  J Sedlak; R H Lindsay
Journal:  Anal Biochem       Date:  1968-10-24       Impact factor: 3.365

Review 6.  The biochemical production of ferrihemoglobin-forming derivatives from aromatic amines, and mechanisms of ferrihemoglobin formation.

Authors:  M Kiese
Journal:  Pharmacol Rev       Date:  1966-09       Impact factor: 25.468

7.  Superoxide dismutase isozymes of rat lung.

Authors:  P Kakkar; P N Viswanathan
Journal:  Indian J Biochem Biophys       Date:  1986-12       Impact factor: 1.918

8.  A modified spectrophotometric assay of superoxide dismutase.

Authors:  P Kakkar; B Das; P N Viswanathan
Journal:  Indian J Biochem Biophys       Date:  1984-04       Impact factor: 1.918

9.  Effect of anaesthetic ether on lipid peroxidation and superoxide dismutase isozymes of young and adult rat brain.

Authors:  S Awasthi; P Kakkar; P N Viswanathan; R Bharadwaj
Journal:  Indian J Exp Biol       Date:  1989-07       Impact factor: 0.818

Review 10.  Three models of free radical-induced cell injury.

Authors:  M Comporti
Journal:  Chem Biol Interact       Date:  1989       Impact factor: 5.192

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  1 in total

1.  Endoplasmic reticulum stress in spinal and bulbar muscular atrophy: a potential target for therapy.

Authors:  Karli Montague; Bilal Malik; Anna L Gray; Albert R La Spada; Michael G Hanna; Gyorgy Szabadkai; Linda Greensmith
Journal:  Brain       Date:  2014-06-04       Impact factor: 13.501

  1 in total

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