Literature DB >> 14566855

Uterine leiomyoma in the Eker rat: a unique model for important diseases of women.

Cheryl Lyn Walker1, Deborah Hunter, Jeffery I Everitt.   

Abstract

Eker rats carry a defect in the Tsc-2 tumor suppressor gene and female Eker rats develop uterine leiomyoma with a high frequency. The presentation, response to hormones and molecular alterations in these mesenchymal smooth muscle tumors, closely resembles their cognate human disease. Female rats and tumor-derived cell lines from Eker rat leiomyomas (ELT lines) have been developed as an in vivo/in vitro model system for preclinical studies to identify novel therapeutic agents for this disease and for studying disease pathogenesis. In addition to serving as a model for uterine leiomyoma, Eker rats have proven valuable for studying lymphangioleiomyomatosis, a related proliferative smooth muscle disease of women. Copyright 2003 Wiley-Liss, Inc.

Entities:  

Mesh：

Year:  2003        PMID： 14566855     DOI： 10.1002/gcc.10281

Source DB:  PubMed          Journal:  Genes Chromosomes Cancer        ISSN： 1045-2257            Impact factor:   5.006


  27 in total

1.  Immunoexpression of Steroid Hormone Receptors and Proliferation Markers in Uterine Leiomyoma and Normal Myometrial Tissues from the Miniature Pig, Sus scrofa.

Authors:  Kristie Mozzachio; Alicia B Moore; Grace E Kissling; Darlene Dixon
Journal:  Toxicol Pathol       Date:  2015-12-20       Impact factor: 1.902

2.  Loss of inhibitory insulin receptor substrate-1 phosphorylation is an early event in mammalian target of rapamycin-dependent endometrial hyperplasia and carcinoma.

Authors:  Adrienne S McCampbell; Heather A Harris; Judy S Crabtree; Richard C Winneker; Cheryl L Walker; Russell R Broaddus
Journal:  Cancer Prev Res (Phila)       Date:  2010-02-23

Review 3.  A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays.

Authors:  Phyllis C Leppert; William H Catherino; James H Segars
Journal:  Am J Obstet Gynecol       Date:  2006-04-25       Impact factor: 8.661

4.  Proceedings from the Third National Institutes of Health International Congress on Advances in Uterine Leiomyoma Research: comprehensive review, conference summary and future recommendations.

Authors:  James H Segars; Estella C Parrott; Joan D Nagel; Xiaoxiao Catherine Guo; Xiaohua Gao; Linda S Birnbaum; Vivian W Pinn; Darlene Dixon
Journal:  Hum Reprod Update       Date:  2014-01-08       Impact factor: 15.610

Review 5.  Minireview: Lymphangioleiomyomatosis (LAM): The "Other" Steroid-Sensitive Cancer.

Authors:  Hen Prizant; Stephen R Hammes
Journal:  Endocrinology       Date:  2016-07-13       Impact factor: 4.736

6.  Developmental Environmental Exposure Alters the Epigenetic Features of Myometrial Stem Cells.

Authors:  Qiwei Yang; Ayman Al-Hendy
Journal:  Gynecol Obstet Res       Date:  2016-12-01

7.  Environmental estrogens differentially engage the histone methyltransferase EZH2 to increase risk of uterine tumorigenesis.

Authors:  K Leigh Greathouse; Tiffany Bredfeldt; Jeffrey I Everitt; Kevin Lin; Tia Berry; Kurunthachalam Kannan; Megan L Mittelstadt; Shuk-mei Ho; Cheryl L Walker
Journal:  Mol Cancer Res       Date:  2012-04       Impact factor: 5.852

8.  Endocrine disruptor exposure during development increases incidence of uterine fibroids by altering DNA repair in myometrial stem cells.

Authors:  Lauren E Prusinski Fernung; Qiwei Yang; Daitoku Sakamuro; Alpana Kumari; Aymara Mas; Ayman Al-Hendy
Journal:  Biol Reprod       Date:  2018-10-01       Impact factor: 4.285

Review 9.  Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing.

Authors:  D Andrew Crain; Sarah J Janssen; Thea M Edwards; Jerrold Heindel; Shuk-mei Ho; Patricia Hunt; Taisen Iguchi; Anders Juul; John A McLachlan; Jackie Schwartz; Niels Skakkebaek; Ana M Soto; Shanna Swan; Cheryl Walker; Teresa K Woodruff; Tracey J Woodruff; Linda C Giudice; Louis J Guillette
Journal:  Fertil Steril       Date:  2008-10       Impact factor: 7.329

10.  AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27.

Authors:  John D Short; Kevin D Houston; Ruhee Dere; Sheng-Li Cai; Jinhee Kim; Charles L Johnson; Russell R Broaddus; Jianjun Shen; Susie Miyamoto; Fuyuhiko Tamanoi; David Kwiatkowski; Gordon B Mills; Cheryl Lyn Walker
Journal:  Cancer Res       Date:  2008-08-15       Impact factor: 12.701
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