Literature DB >> 14566344

A functional genetic variation of the 5-HT2a receptor affects human memory.

Dominique J-F de Quervain1, Katharina Henke, Amanda Aerni, Daniel Coluccia, M Axel Wollmer, Christoph Hock, Roger M Nitsch, Andreas Papassotiropoulos.   

Abstract

Human memory capacity is highly variable across individuals and is influenced by both genetic and environmental factors. A roughly 50% heritability estimate indicates that naturally occurring genetic variations have an important impact on this cognitive ability. Therefore, we investigated a functional variation of a memory-related serotonin receptor in 349 healthy young volunteers, and found 21% poorer memory performance in subjects with the rare variant.

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Year:  2003        PMID: 14566344     DOI: 10.1038/nn1146

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN: 1097-6256            Impact factor:   24.884


  42 in total

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2.  Presynaptic serotonin 2A receptors modulate thalamocortical plasticity and associative learning.

Authors:  Alexander Barre; Coralie Berthoux; Dimitri De Bundel; Emmanuel Valjent; Joël Bockaert; Philippe Marin; Carine Bécamel
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-22       Impact factor: 11.205

3.  K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation.

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Journal:  EMBO J       Date:  2014-07-14       Impact factor: 11.598

4.  Variation in Dopamine D2 and Serotonin 5-HT2A Receptor Genes is Associated with Working Memory Processing and Response to Treatment with Antipsychotics.

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Journal:  Neuropsychopharmacology       Date:  2015-01-07       Impact factor: 7.853

5.  Interaction of dopamine system genes and cognitive functions in patients with schizophrenia and their relatives and in healthy subjects from the general population.

Authors:  M V Alfimova; V E Golimbet; I K Gritsenko; T V Lezheiko; L I Abramova; M A Strel'tsova; I V Khlopina; R Ebstein
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6.  Cognitive flexibility is associated with KIBRA variant and modulated by recent tobacco use.

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7.  Multiple regulatory variants modulate expression of 5-hydroxytryptamine 2A receptors in human cortex.

Authors:  Ryan M Smith; Audrey C Papp; Amy Webb; Cara L Ruble; Leanne M Munsie; Laura K Nisenbaum; Joel E Kleinman; Barbara K Lipska; Wolfgang Sadee
Journal:  Biol Psychiatry       Date:  2012-11-13       Impact factor: 13.382

Review 8.  The impact of genetic research on our understanding of normal cognitive ageing: 1995 to 2009.

Authors:  Antony Payton
Journal:  Neuropsychol Rev       Date:  2009-09-19       Impact factor: 7.444

9.  Additive genetic risk from five serotonin system polymorphisms interacts with interpersonal stress to predict depression.

Authors:  Suzanne Vrshek-Schallhorn; Catherine B Stroud; Susan Mineka; Richard E Zinbarg; Emma K Adam; Eva E Redei; Constance Hammen; Michelle G Craske
Journal:  J Abnorm Psychol       Date:  2015-11

Review 10.  Functional anatomy of 5-HT2A receptors in the amygdala and hippocampal complex: relevance to memory functions.

Authors:  Cristiano Bombardi; Giuseppe Di Giovanni
Journal:  Exp Brain Res       Date:  2013-04-17       Impact factor: 1.972

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