Literature DB >> 14565548

A validated high performance liquid chromatographic method for analysis of nicotine in pure form and from formulations.

Kaustubh R Tambwekar1, Ritesh B Kakariya, Sanjay Garg.   

Abstract

A reverse phase HPLC method using C18 column has been developed for the quantitative estimation of nicotine in the bulk material and formulations (extended release and immediate release dosage forms). The method is specific to nicotine (RT approximately 4.64 min, asymmetry approximately 1.75), and can resolve analyte peak from excipient interferences. It is linear (coefficient of variation approximately 0.9993), accurate (average recovery approximately 100%), and passed all the system suitability requirements. Applicability of the method was evaluated in analysis of drug-excipient compatibility samples, commercial dosage form (such as nicotine gum) and two novel in-house formulations.

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Year:  2003        PMID： 14565548     DOI： 10.1016/s0731-7085(03)00236-x

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN： 0731-7085            Impact factor:   3.935


  10 in total

1.  Effect of surfactants and pH on naltrexone (NTX) permeation across buccal mucosa.

Authors:  Vishwas Rai; Hock S Tan; Bozena Michniak-Kohn
Journal:  Int J Pharm       Date:  2011-04-04       Impact factor: 5.875

2.  Paper-Based Potentiometric Sensors for Nicotine Determination in Smokers' Sweat.

Authors:  Abd El-Galil E Amr; Ayman H Kamel; Abdulrahman A Almehizia; Ahmed Y A Sayed; Elsayed A Elsayed; Hisham S M Abd-Rabboh
Journal:  ACS Omega       Date:  2021-04-22

3.  Genotoxicity of Nicotiana tabacum leaves on Helix aspersa.

Authors:  Fernanda R da Silva; Bernardo Erdtmann; Tiago Dalpiaz; Emilene Nunes; Alexandre Ferraz; Tales L C Martins; Johny F Dias; Darlan P da Rosa; Marilene Porawskie; Silvia Bona; Juliana da Silva
Journal:  Genet Mol Biol       Date:  2013-05-17       Impact factor: 1.771

Review 4.  The in vitro toxicology of Swedish snus.

Authors:  Christopher R E Coggins; Mark Ballantyne; Margareta Curvall; Lars-Erik Rutqvist
Journal:  Crit Rev Toxicol       Date:  2012-03-09       Impact factor: 5.635

5.  Evaluation of the effect of nicotine and metabolites on the periodontal status and the mRNA expression of interleukin-1β in smokers with chronic periodontitis.

Authors:  Ajita Meenawat; Vivek Govila; Sudhir Goel; Sunil Verma; Karan Punn; Vivek Srivastava; Rameshwar Shantaram Dolas
Journal:  J Indian Soc Periodontol       Date:  2015 Jul-Aug

6.  Extract of Nicotiana tabacum as a potential control agent of Grapholita molesta (Lepidoptera: Tortricidae).

Authors:  Souvic Sarker; Un Taek Lim
Journal:  PLoS One       Date:  2018-08-23       Impact factor: 3.240

7.  Influence of Smoking on Gingival Crevicular Fluid Interleukin 1β and Interleukin-8 in Patients with Severe Chronic Periodontitis among a Rural Population in India.

Authors:  Ritu Prabha Patel; Ramesh Amirisetty; Butchibabu Kalakonda; Narendra Varma Penumatsa; Pradeep Koppolu
Journal:  Niger Med J       Date:  2018 Jul-Aug

8.  Anti-inflammatory activity of nicotine isolated from Brassica oleracea in rheumatoid arthritis.

Authors:  Bharti Rakhecha; Prachi Agnihotri; Tikam Chand Dakal; Mohd Saquib; Sagarika Biswas
Journal:  Biosci Rep       Date:  2022-04-29       Impact factor: 3.976

9.  Development and validation of reversed phase high-performance liquid chromatography method for estimation of lercanidipine HCl in pure form and from nanosuspension formulation.

Authors:  Ankita D Chonkar; Renuka S Managuli; Josyula Venkata Rao; Nayanabhirama Udupa
Journal:  J Basic Clin Pharm       Date:  2015-12

10.  A Stability Indicating HPLC Method to Determine Actual Content and Stability of Nicotine within Electronic Cigarette Liquids.

Authors:  Mahima Bansal; Manisha Sharma; Chris Bullen; Darren Svirskis
Journal:  Int J Environ Res Public Health       Date:  2018-08-13       Impact factor: 3.390
  10 in total

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