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Literature DB >> 14564008

Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking.

Maxime Dahan¹, Sabine Lévi, Camilla Luccardini, Philippe Rostaing, Béatrice Riveau, Antoine Triller.

Abstract

Semiconductor quantum dots (QDs) are nanometer-sized fluorescent probes suitable for advanced biological imaging. We used QDs to track individual glycine receptors (GlyRs) and analyze their lateral dynamics in the neuronal membrane of living cells for periods ranging from milliseconds to minutes. We characterized multiple diffusion domains in relation to the synaptic, perisynaptic, or extrasynaptic GlyR localization. The entry of GlyRs into the synapse by diffusion was observed and further confirmed by electron microscopy imaging of QD-tagged receptors.

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Year: 2003 PMID： 14564008 DOI： 10.1126/science.1088525

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

338 in total

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Review 2. Biocompatible quantum dots for biological applications.

Authors: Sandra J Rosenthal; Jerry C Chang; Oleg Kovtun; James R McBride; Ian D Tomlinson
Journal: Chem Biol Date: 2011-01-28

Review 3. Photophysics of fluorescent probes for single-molecule biophysics and super-resolution imaging.

Authors: Taekjip Ha; Philip Tinnefeld
Journal: Annu Rev Phys Chem Date: 2012-01-30 Impact factor: 12.703

4. Intracellular association of glycine receptor with gephyrin increases its plasma membrane accumulation rate.

Authors: Cyril Hanus; Christian Vannier; Antoine Triller
Journal: J Neurosci Date: 2004-02-04 Impact factor: 6.167

5. Structural basis of dynamic glycine receptor clustering by gephyrin.

Authors: Maria Sola; Vassiliy N Bavro; Joanna Timmins; Thomas Franz; Sylvie Ricard-Blum; Guy Schoehn; Rob W H Ruigrok; Ingo Paarmann; Taslimarif Saiyed; Gregory A O'Sullivan; Bertram Schmitt; Heinrich Betz; Winfried Weissenhorn
Journal: EMBO J Date: 2004-06-17 Impact factor: 11.598

Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking.

1. Three-dimensional tracking of single mRNA particles in Saccharomyces cerevisiae using a double-helix point spread function.

Review 2. Biocompatible quantum dots for biological applications.

Review 3. Photophysics of fluorescent probes for single-molecule biophysics and super-resolution imaging.

4. Intracellular association of glycine receptor with gephyrin increases its plasma membrane accumulation rate.

5. Structural basis of dynamic glycine receptor clustering by gephyrin.

Review 6. Imaging gene expression in single living cells.

7. Quantum dot fluorescence characterizes the nanoscale organization of T cell receptors for antigen.

Review 8. Detection, counting, and imaging of single nanoparticles.

Review 9. Quantum dots in diagnostics and detection: principles and paradigms.

10. Confocal, three-dimensional tracking of individual quantum dots in high-background environments.