Literature DB >> 14557946

Controlling mesenchymal stem cell differentiation by TGFBeta family members.

Bernard A J Roelen1, Peter ten Dijke.   

Abstract

Mesenchymal stem cells can differentiate into various tissue types including bone, cartilage, fat, and muscle. Transforming growth factor-Beta (TGFBeta) family members, including TGFBetas and bone morphogenetic proteins (BMPs), play important roles in directing fate decisions for mesenchymal stem cells. TGFBeta can provide competence for early stages of chondroblastic and osteoblastic differentiation, but it inhibits myogenesis, adipogenesis, and late-stage osteoblast differentiation. BMPs also inhibit adipogenesis and myogenesis, but they strongly promote osteoblast differentiation. TGFBeta family members signal via specific serine/threonine kinase receptors and their nuclear effectors, termed Smad proteins. In this review we discuss recent advances in our understanding of the molecular mechanisms by which TGFBeta family members control mesenchymal stem cell differentiation.

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Year:  2003        PMID： 14557946     DOI： 10.1007/s00776-003-0702-2

Source DB:  PubMed          Journal:  J Orthop Sci        ISSN： 0949-2658            Impact factor:   1.601


  47 in total

1.  Mesenchymal stem cells from umbilical cord blood: parameters for isolation, characterization and adipogenic differentiation.

Authors:  Tatiana Taís Sibov; P Severino; L C Marti; L F Pavon; D M Oliveira; P R Tobo; A H Campos; A T Paes; E Amaro; L F Gamarra; C A Moreira-Filho
Journal:  Cytotechnology       Date:  2012-02-12       Impact factor: 2.058

Review 2.  Paget disease of bone.

Authors:  G David Roodman; Jolene J Windle
Journal:  J Clin Invest       Date:  2005-02       Impact factor: 14.808

3.  Ossifying fibroma tumor stem cells are maintained by epigenetic regulation of a TSP1/TGF-β/SMAD3 autocrine loop.

Authors:  Haiyan Qin; Cunye Qu; Takayoshi Yamaza; Ruili Yang; Xia Lin; Xue-Yan Duan; Kentaro Akiyama; Yi Liu; Qunzhou Zhang; Chider Chen; Yibu Chen; Hank Heng Qi; Xin-Hua Feng; Anh D Le; Songtao Shi
Journal:  Cell Stem Cell       Date:  2013-11-07       Impact factor: 24.633

4.  An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells.

Authors:  Qing Chen; Peishun Shou; Liying Zhang; Chunliang Xu; Chunxing Zheng; Yanyan Han; Wenzhao Li; Yin Huang; Xiaoren Zhang; Changshun Shao; Arthur I Roberts; Arnold B Rabson; Guangwen Ren; Yanyun Zhang; Ying Wang; David T Denhardt; Yufang Shi
Journal:  Stem Cells       Date:  2014-02       Impact factor: 6.277

Review 5.  Biological functions of mesenchymal stem cells and clinical implications.

Authors:  Abderrahim Naji; Masamitsu Eitoku; Benoit Favier; Frédéric Deschaseaux; Nathalie Rouas-Freiss; Narufumi Suganuma
Journal:  Cell Mol Life Sci       Date:  2019-05-04       Impact factor: 9.261

6.  miR-20a regulates adipocyte differentiation by targeting lysine-specific demethylase 6b and transforming growth factor-β signaling.

Authors:  J Zhou; F Guo; G Wang; J Wang; F Zheng; X Guan; A Chang; X Zhang; C Dai; S Li; X Li; B Wang
Journal:  Int J Obes (Lond)       Date:  2015-03-30       Impact factor: 5.095

7.  A modular versatile chip carrier for high-throughput screening of cell-biomaterial interactions.

Authors:  H V Unadkat; R R Rewagad; M Hulsman; G F B Hulshof; R K Truckenmüller; D F Stamatialis; M J T Reinders; J C T Eijkel; A van den Berg; C A van Blitterswijk; J de Boer
Journal:  J R Soc Interface       Date:  2013-01-06       Impact factor: 4.118

8.  Transforming growth factor-β in stem cells and tissue homeostasis.

Authors:  Xin Xu; Liwei Zheng; Quan Yuan; Gehua Zhen; Janet L Crane; Xuedong Zhou; Xu Cao
Journal:  Bone Res       Date:  2018-01-31       Impact factor: 13.567

9.  Gene expression patterns in hepatic tissue and visceral adipose tissue of patients with non-alcoholic fatty liver disease.

Authors:  Ancha Baranova; Karen Schlauch; Hazem Elariny; Mohammed Jarrar; Chase Bennett; Clare Nugent; Shobha J Gowder; Zahra Younoszai; Rochelle Collantes; Vikas Chandhoke; Zobair M Younossi
Journal:  Obes Surg       Date:  2007-08       Impact factor: 4.129

10.  Differences in fat and muscle mass associated with a functional human polymorphism in a post-transcriptional BMP2 gene regulatory element.

Authors:  Joseph M Devaney; Laura L Tosi; David T Fritz; Heather A Gordish-Dressman; Shan Jiang; Funda E Orkunoglu-Suer; Andrew H Gordon; Brennan T Harmon; Paul D Thompson; Priscilla M Clarkson; Theodore J Angelopoulos; Paul M Gordon; Niall M Moyna; Linda S Pescatello; Paul S Visich; Robert F Zoeller; Cinzia Brandoli; Eric P Hoffman; Melissa B Rogers
Journal:  J Cell Biochem       Date:  2009-08-15       Impact factor: 4.429
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