Literature DB >> 14557668

Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear accumulation.

Jason J Rodriguez1, Lin-Fa Wang, Curt M Horvath.   

Abstract

The V protein of the recently emerged paramyxovirus, Nipah virus, has been shown to inhibit interferon (IFN) signal transduction through cytoplasmic sequestration of cellular STAT1 and STAT2 in high-molecular-weight complexes. Here we demonstrate that the closely related Hendra virus V protein also inhibits cellular responses to IFN through binding and cytoplasmic sequestration of both STAT1 and STAT2, but not STAT3. These findings demonstrate a V protein-mediated IFN signal evasion mechanism that is a general property of the known Henipavirus species.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 14557668      PMCID： PMC229371          DOI： 10.1128/jvi.77.21.11842-11845.2003

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  19 in total

Review 1.  RING domains: master builders of molecular scaffolds?

Authors:  K L Borden
Journal:  J Mol Biol       Date:  2000-02-04       Impact factor: 5.469

2.  The paramyxovirus SV5 V protein binds two atoms of zinc and is a structural component of virions.

Authors:  R G Paterson; G P Leser; M A Shaughnessy; R A Lamb
Journal:  Virology       Date:  1995-04-01       Impact factor: 3.616

Review 3.  Molecular biology of Hendra and Nipah viruses.

Authors:  L Wang; B H Harcourt; M Yu; A Tamin; P A Rota; W J Bellini; B T Eaton
Journal:  Microbes Infect       Date:  2001-04       Impact factor: 2.700

Review 4.  The natural history of Hendra and Nipah viruses.

Authors:  H Field; P Young; J M Yob; J Mills; L Hall; J Mackenzie
Journal:  Microbes Infect       Date:  2001-04       Impact factor: 2.700

5.  Nipah virus V protein evades alpha and gamma interferons by preventing STAT1 and STAT2 activation and nuclear accumulation.

Authors:  Jason J Rodriguez; Jean-Patrick Parisien; Curt M Horvath
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

6.  Nipah virus: a recently emergent deadly paramyxovirus.

Authors:  K B Chua; W J Bellini; P A Rota; B H Harcourt; A Tamin; S K Lam; T G Ksiazek; P E Rollin; S R Zaki; W Shieh; C S Goldsmith; D J Gubler; J T Roehrig; B Eaton; A R Gould; J Olson; H Field; P Daniels; A E Ling; C J Peters; L J Anderson; B W Mahy
Journal:  Science       Date:  2000-05-26       Impact factor: 47.728

7.  The V protein of simian virus 5 inhibits interferon signalling by targeting STAT1 for proteasome-mediated degradation.

Authors:  L Didcock; D F Young; S Goodbourn; R E Randall
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

8.  Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains.

Authors:  A D Capili; D C Schultz; F J RauscherIII; K L Borden
Journal:  EMBO J       Date:  2001-01-15       Impact factor: 11.598

9.  The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2.

Authors:  J P Parisien; J F Lau; J J Rodriguez; B M Sullivan; A Moscona; G D Parks; R A Lamb; C M Horvath
Journal:  Virology       Date:  2001-05-10       Impact factor: 3.616

10.  Nipah virus infection in bats (order Chiroptera) in peninsular Malaysia.

Authors:  J M Yob; H Field; A M Rashdi; C Morrissy; B van der Heide; P Rota; A bin Adzhar; J White; P Daniels; A Jamaluddin; T Ksiazek
Journal:  Emerg Infect Dis       Date:  2001 May-Jun       Impact factor: 6.883
View more
  79 in total

1.  Identification of the nuclear export signal and STAT-binding domains of the Nipah virus V protein reveals mechanisms underlying interferon evasion.

Authors:  Jason J Rodriguez; Cristian D Cruz; Curt M Horvath
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103

2.  Dissociation of paramyxovirus interferon evasion activities: universal and virus-specific requirements for conserved V protein amino acids in MDA5 interference.

Authors:  Aparna Ramachandran; Curt M Horvath
Journal:  J Virol       Date:  2010-08-18       Impact factor: 5.103

Review 3.  The role of signal transducer and activator of transcription-2 in the interferon response.

Authors:  Håkan C Steen; Ana M Gamero
Journal:  J Interferon Cytokine Res       Date:  2012-01-26       Impact factor: 2.607

Review 4.  Paramyxovirus disruption of interferon signal transduction: STATus report.

Authors:  Aparna Ramachandran; Curt M Horvath
Journal:  J Interferon Cytokine Res       Date:  2009-09       Impact factor: 2.607

5.  Foot-and-mouth disease virus structural protein VP3 degrades Janus kinase 1 to inhibit IFN-γ signal transduction pathways.

Authors:  Dan Li; Jin Wei; Fan Yang; Hua-Nan Liu; Zi-Xiang Zhu; Wei-Jun Cao; Shu Li; Xiang-Tao Liu; Hai-Xue Zheng; Hong-Bing Shu
Journal:  Cell Cycle       Date:  2016       Impact factor: 4.534

Review 6.  Paramyxovirus evasion of innate immunity: Diverse strategies for common targets.

Authors:  Michelle D Audsley; Gregory W Moseley
Journal:  World J Virol       Date:  2013-05-12

7.  Viral immune modulators perturb the human molecular network by common and unique strategies.

Authors:  Andreas Pichlmair; Kumaran Kandasamy; Gualtiero Alvisi; Orla Mulhern; Roberto Sacco; Matthias Habjan; Marco Binder; Adrijana Stefanovic; Carol-Ann Eberle; Adriana Goncalves; Tilmann Bürckstümmer; André C Müller; Astrid Fauster; Cathleen Holze; Kristina Lindsten; Stephen Goodbourn; Georg Kochs; Friedemann Weber; Ralf Bartenschlager; Andrew G Bowie; Keiryn L Bennett; Jacques Colinge; Giulio Superti-Furga
Journal:  Nature       Date:  2012-07-26       Impact factor: 49.962

8.  A single amino acid substitution in the V protein of Nipah virus alters its ability to block interferon signalling in cells from different species.

Authors:  Kathrin Hagmaier; Nicola Stock; Steve Goodbourn; Lin-Fa Wang; Richard Randall
Journal:  J Gen Virol       Date:  2006-12       Impact factor: 3.891

9.  The nonstructural proteins of Nipah virus play a key role in pathogenicity in experimentally infected animals.

Authors:  Misako Yoneda; Vanessa Guillaume; Hiroki Sato; Kentaro Fujita; Marie-Claude Georges-Courbot; Fusako Ikeda; Mio Omi; Yuri Muto-Terao; T Fabian Wild; Chieko Kai
Journal:  PLoS One       Date:  2010-09-15       Impact factor: 3.240

10.  Mapuera virus, a rubulavirus that inhibits interferon signalling in a wide variety of mammalian cells without degrading STATs.

Authors:  K Hagmaier; N Stock; B Precious; K Childs; L-F Wang; S Goodbourn; R E Randall
Journal:  J Gen Virol       Date:  2007-03       Impact factor: 3.891
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.