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Literature DB >> 22280068

The role of signal transducer and activator of transcription-2 in the interferon response.

Abstract

The signal transducer and activator of transcription-2 (STAT2) was discovered as a cellular component of the DNA binding complex known as interferon (IFN) stimulated gene factor-3. Numerous studies have confirmed that STAT2 operates as a positive regulator in the transcriptional activation response elicited by IFNs. In this article, we highlight the progress made in elucidating the pivotal role of STAT2 in driving the expression of IFN-induced genes, innate antiviral immunity, apoptosis, and cancer. A better understanding of the functional role of STAT2 in the IFN response and how STAT2 is regulated will uncover new clues to its role in diseases.

Entities: Disease Gene

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Year: 2012 PMID： 22280068 PMCID： PMC3680977 DOI： 10.1089/jir.2011.0099

Source DB: PubMed Journal: J Interferon Cytokine Res ISSN： 1079-9907 Impact factor: 2.607

73 in total

1. Biologic consequences of Stat1-independent IFN signaling.

Authors: M P Gil; E Bohn; A K O'Guin; C V Ramana; B Levine; G R Stark; H W Virgin; R D Schreiber
Journal: Proc Natl Acad Sci U S A Date: 2001-06-05 Impact factor: 11.205

2. Immune response in Stat2 knockout mice.

Authors: C Park; S Li; E Cha; C Schindler
Journal: Immunity Date: 2000-12 Impact factor: 31.745

3. The interferon-inducible Stat2:Stat1 heterodimer preferentially binds in vitro to a consensus element found in the promoters of a subset of interferon-stimulated genes.

Authors: J J Ghislain; T Wong; M Nguyen; E N Fish
Journal: J Interferon Cytokine Res Date: 2001-06 Impact factor: 2.607

4. Chromatin dynamics of gene activation and repression in response to interferon alpha (IFN(alpha)) reveal new roles for phosphorylated and unphosphorylated forms of the transcription factor STAT2.

Authors: Barbara Testoni; Christine Völlenkle; Francesca Guerrieri; Sabine Gerbal-Chaloin; Giovanni Blandino; Massimo Levrero
Journal: J Biol Chem Date: 2011-04-15 Impact factor: 5.157

5. IFN-Stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff.

Authors: Matthew Paulson; Carolyn Press; Eric Smith; Naoko Tanese; David E Levy
Journal: Nat Cell Biol Date: 2002-02 Impact factor: 28.824

6. Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs.

Authors: K Melen; L Kinnunen; I Julkunen
Journal: J Biol Chem Date: 2001-01-09 Impact factor: 5.157

7. Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2.

Authors: J D Farrar; J D Smith; T L Murphy; S Leung; G R Stark; K M Murphy
Journal: Nat Immunol Date: 2000-07 Impact factor: 25.606

8. pp32, an INHAT component, is a transcription machinery recruiter for maximal induction of IFN-stimulated genes.

Authors: Shinichi Kadota; Kyosuke Nagata
Journal: J Cell Sci Date: 2011-02-15 Impact factor: 5.285

9. Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors.

Authors: J F Lau; J P Parisien; C M Horvath
Journal: Proc Natl Acad Sci U S A Date: 2000-06-20 Impact factor: 11.205

10. STAT2 mediates innate immunity to Dengue virus in the absence of STAT1 via the type I interferon receptor.

Authors: Stuart T Perry; Michael D Buck; Steven M Lada; Christian Schindler; Sujan Shresta
Journal: PLoS Pathog Date: 2011-02-17 Impact factor: 6.823

12 in total

1. Promyelocytic Leukemia Protein (PML) Requirement for Interferon-induced Global Cellular SUMOylation.

Authors: Mohamed Ali Maroui; Ghizlane Maarifi; Francis P McManus; Frédéric Lamoliatte; Pierre Thibault; Mounira K Chelbi-Alix
Journal: Mol Cell Proteomics Date: 2018-03-13 Impact factor: 5.911

2. Expression Profile of Genes Related to the Th17 Pathway in Macrophages Infected by Leishmania major and Leishmania amazonensis: The Use of Gene Regulatory Networks in Modeling This Pathway.

Authors: Leilane Oliveira Gonçalves; Andrés F Vallejo Pulido; Fernando Augusto Siqueira Mathias; Alexandre Estevão Silvério Enes; Maria Gabriela Reis Carvalho; Daniela de Melo Resende; Marta E Polak; Jeronimo C Ruiz
Journal: Front Cell Infect Microbiol Date: 2022-06-14 Impact factor: 6.073

3. IFN-α suppresses GATA3 transcription from a distal exon and promotes H3K27 trimethylation of the CNS-1 enhancer in human Th2 cells.

Authors: Jonathan P Huber; Sarah R Gonzales-van Horn; Kole T Roybal; Michelle A Gill; J David Farrar
Journal: J Immunol Date: 2014-05-09 Impact factor: 5.422

Review 10. A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses.

Authors: Agata Michalska; Katarzyna Blaszczyk; Joanna Wesoly; Hans A R Bluyssen
Journal: Front Immunol Date: 2018-05-28 Impact factor: 7.561