| Literature DB >> 14556793 |
Man-Chin Chung1, Rafael Victório Carvalho Güido, Tatiane Favarato Martinelli, Marinei Ferreira Gonçalves, Michelle Carneiro Polli, Katia Cirlene Alves Botelho, Eliana Aparecida Varanda, Walter Colli, M Terêsa M Miranda, Elizabeth Igne Ferreira.
Abstract
The synthesis of mutual prodrugs of nitrofurazone with primaquine, using specific and nonspecific spacer groups, has been previously attempted seeking selective antichagasic agents. The intermediate reaction product, hydroxymethylnitrofurazone (NFOH-121), was isolated and tested in LLC-MK(2) culture cells infected with trypomastigotes forms of Trypanosoma cruzi showing higher trypanocidal activity than nitrofurazone and benznidazol in all stages. The mutagenicity tests showed that the prodrug was less toxic than the parent drug. Degradation assays were carried out in pH 1.2 and 7.4.Entities:
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Year: 2003 PMID： 14556793 DOI： 10.1016/j.bmc.2003.07.004
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641