Literature DB >> 14555959

Human antibodies from immunized donors are protective against anthrax toxin in vivo.

Martha A Wild1, Hong Xin, Toshiaki Maruyama, Mary Jean Nolan, Peter M Calveley, John D Malone, Mark R Wallace, Katherine S Bowdish.   

Abstract

A panel of Fabs that neutralize anthrax toxin in vitro was selected from libraries generated from human donors vaccinated against anthrax. At least two of these antibodies protect rats from anthrax intoxication in vivo. Fabs 83K7C and 63L1D bind with subnanomolar affinity to protective antigen (PA) 63, and Fab 63L1D neutralizes toxin substoichiometrically, inhibits lethal factor (LF) interaction with PA63 and binds to a conformational epitope formed by PA63.

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Year:  2003        PMID： 14555959     DOI： 10.1038/nbt891

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


  37 in total

1.  Protective antigen and toxin neutralization antibody patterns in anthrax vaccinees undergoing serial plasmapheresis.

Authors:  Phillip R Pittman; Susan F Leitman; Julio G Barrera Oro; Sarah L Norris; Nina M Marano; Manmohan V Ranadive; Bonnie S Sink; Kelly T McKee
Journal:  Clin Diagn Lab Immunol       Date:  2005-06

Review 2.  Genetic medicine strategies to protect against bioterrorism.

Authors:  Julie L Boyer; Ronald G Crystal
Journal:  Trans Am Clin Climatol Assoc       Date:  2006

3.  Non-human primate immune libraries combined with germline humanization: an (almost) new, and powerful approach for the isolation of therapeutic antibodies.

Authors:  Thibaut Pelat; Philippe Thullier
Journal:  MAbs       Date:  2009-07-05       Impact factor: 5.857

4.  Human monoclonal antibodies generated following vaccination with AVA provide neutralization by blocking furin cleavage but not by preventing oligomerization.

Authors:  Kenneth Smith; Sherry R Crowe; Lori Garman; Carla J Guthridge; Jennifer J Muther; Emily McKee; Nai-Ying Zheng; A Darise Farris; Joel M Guthridge; Patrick C Wilson; Judith A James
Journal:  Vaccine       Date:  2012-03-14       Impact factor: 3.641

Review 5.  Obstructing toxin pathways by targeted pore blockage.

Authors:  Ekaterina M Nestorovich; Sergey M Bezrukov
Journal:  Chem Rev       Date:  2012-10-11       Impact factor: 60.622

6.  Selection of a macaque Fab with framework regions like those in humans, high affinity, and ability to neutralize the protective antigen (PA) of Bacillus anthracis by binding to the segment of PA between residues 686 and 694.

Authors:  Emmanuelle Laffly; Ludivine Danjou; Florence Condemine; Dominique Vidal; Emmanuel Drouet; Marie-Paule Lefranc; Chantal Bottex; Philippe Thullier
Journal:  Antimicrob Agents Chemother       Date:  2005-08       Impact factor: 5.191

7.  Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening.

Authors:  Ludovic Bannwarth; Allison B Goldberg; Catherine Chen; Benjamin E Turk
Journal:  Chem Biol       Date:  2012-07-27

8.  The structure of tumor endothelial marker 8 (TEM8) extracellular domain and implications for its receptor function for recognizing anthrax toxin.

Authors:  Sheng Fu; Xiaohang Tong; Chenguang Cai; Ying Zhao; Yang Wu; Yuanyuan Li; Junjie Xu; Xuejun C Zhang; Long Xu; Wei Chen; Zihe Rao
Journal:  PLoS One       Date:  2010-06-18       Impact factor: 3.240

Review 9.  Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins.

Authors:  Holger Barth; Klaus Aktories; Michel R Popoff; Bradley G Stiles
Journal:  Microbiol Mol Biol Rev       Date:  2004-09       Impact factor: 11.056

10.  Selection and characterization of human antibodies neutralizing Bacillus anthracis toxin.

Authors:  Bin Zhou; Charlotte Carney; Kim D Janda
Journal:  Bioorg Med Chem       Date:  2007-11-05       Impact factor: 3.641
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