Literature DB >> 14552750

Identification of potent and novel small-molecule inhibitors of caspase-3.

Darin A Allen1, Phuongly Pham, Ingrid C Choong, Bruce Fahr, Matthew T Burdett, Willard Lew, Warren L DeLano, Eric M Gordon, Joni W Lam, Tom O'Brien, Dennis Lee.   

Abstract

The design and synthesis of a series of novel, reversible, small molecule inhibitors of caspase-3 are described.

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Year:  2003        PMID: 14552750     DOI: 10.1016/j.bmcl.2003.08.024

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  Small Molecule Active Site Directed Tools for Studying Human Caspases.

Authors:  Marcin Poreba; Aleksandra Szalek; Paulina Kasperkiewicz; Wioletta Rut; Guy S Salvesen; Marcin Drag
Journal:  Chem Rev       Date:  2015-11-09       Impact factor: 60.622

Review 2.  Therapeutic approaches to preventing cell death in Huntington disease.

Authors:  Anna Kaplan; Brent R Stockwell
Journal:  Prog Neurobiol       Date:  2012-08-28       Impact factor: 11.685

3.  Structural analysis of caspase-1 inhibitors derived from Tethering.

Authors:  Tom O'Brien; Bruce T Fahr; Michelle M Sopko; Joni W Lam; Nathan D Waal; Brian C Raimundo; Hans E Purkey; Phuongly Pham; Michael J Romanowski
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2005-04-09
  3 in total

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