Literature DB >> 14552650

Interactions of antidepressants with neurotransmitter transporters and receptors and their clinical relevance.

Elliott Richelson1.   

Abstract

This review discusses the pharmacology of antidepressants as it relates to their blockade of human transporters for norepinephrine, serotonin, and dopamine, as well as their blockade of several different human neurotransmitter receptors. This blockade by antidepressants of transporters and receptors is thought to relate to therapeutic and adverse effects of these compounds. Knowledge of the preclinical pharmacology of antidepressants will help the clinician to identify adverse effects and drug interactions that may occur with these agents. The article also reviews drugs that have dual action (effects on serotonin and norepinephrine), which may provide a therapeutic advantage in treating depressed patients.

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Year:  2003        PMID： 14552650

Source DB:  PubMed          Journal:  J Clin Psychiatry        ISSN： 0160-6689            Impact factor:   4.384


  24 in total

1.  The novel trisubstituted pyran derivative D-142 has triple monoamine reuptake inhibitory activity and exerts potent antidepressant-like activity in rodents.

Authors:  Aloke K Dutta; Bhaskar Gopishetty; Sanjib Gogoi; Solav Ali; Juan Zhen; Maarten Reith
Journal:  Eur J Pharmacol       Date:  2011-09-24       Impact factor: 4.432

2.  Influence of initial use of serotonergic antidepressants on antiparkinsonian drug use in levodopa-using patients.

Authors:  Maurits E L Arbouw; Kris L L Movig; Cees Neef; Henk-Jan Guchelaar; Toine C G Egberts
Journal:  Eur J Clin Pharmacol       Date:  2007-01-03       Impact factor: 2.953

3.  Antidepressant and Antipsychotic Drugs.

Authors:  Andrew D Krystal
Journal:  Sleep Med Clin       Date:  2010-12-01

Review 4.  Tricyclic antidepressant pharmacology and therapeutic drug interactions updated.

Authors:  P K Gillman
Journal:  Br J Pharmacol       Date:  2007-04-30       Impact factor: 8.739

5.  Phosphorylation of MeCP2 at Ser421 contributes to chronic antidepressant action.

Authors:  Ashley N Hutchinson; Jay V Deng; Sonia Cohen; Anne E West
Journal:  J Neurosci       Date:  2012-10-10       Impact factor: 6.167

6.  Use of anti-depressants and the risk of fracture of the hip or femur.

Authors:  M W M van den Brand; S Pouwels; M M Samson; T P van Staa; B Thio; C Cooper; H G M Leufkens; A C G Egberts; H J J Verhaar; F de Vries
Journal:  Osteoporos Int       Date:  2009-02-24       Impact factor: 4.507

7.  Genome of the Chinese tree shrew.

Authors:  Yu Fan; Zhi-Yong Huang; Chang-Chang Cao; Ce-Shi Chen; Yuan-Xin Chen; Ding-Ding Fan; Jing He; Hao-Long Hou; Li Hu; Xin-Tian Hu; Xuan-Ting Jiang; Ren Lai; Yong-Shan Lang; Bin Liang; Sheng-Guang Liao; Dan Mu; Yuan-Ye Ma; Yu-Yu Niu; Xiao-Qing Sun; Jin-Quan Xia; Jin Xiao; Zhi-Qiang Xiong; Lin Xu; Lan Yang; Yun Zhang; Wei Zhao; Xu-Dong Zhao; Yong-Tang Zheng; Ju-Min Zhou; Ya-Bing Zhu; Guo-Jie Zhang; Jun Wang; Yong-Gang Yao
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

8.  Structural exploration of (3S,6S)-6-benzhydryl-N-benzyltetrahydro-2H-pyran-3-amine analogues: identification of potent triple monoamine reuptake inhibitors as potential antidepressants.

Authors:  Soumava Santra; Sanjib Gogoi; Bhaskar Gopishetty; Tamara Antonio; Juan Zhen; Maarten E A Reith; Aloke K Dutta
Journal:  ChemMedChem       Date:  2012-10-11       Impact factor: 3.466

9.  Olanzapine and fluoxetine combination therapy for treatment-resistant depression: review of efficacy, safety, and study design issues.

Authors:  William V Bobo; Richard C Shelton
Journal:  Neuropsychiatr Dis Treat       Date:  2009-07-02       Impact factor: 2.570

10.  Enhanced sensitivity of the MRL/MpJ mouse to the neuroplastic and behavioral effects of chronic antidepressant treatments.

Authors:  Darrick T Balu; Georgia E Hodes; Brian T Anderson; Irwin Lucki
Journal:  Neuropsychopharmacology       Date:  2009-01-28       Impact factor: 7.853
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