Literature DB >> 14550576

Conditional expression of MCM7 increases tumor growth without altering DNA replication activity.

Kenichi Yoshida1, Ituro Inoue.   

Abstract

The minichromosome maintenance (MCM) 2-7 complex is a putative DNA helicase complex that facilitates the initiation of DNA replication. Here, we generated a cell line MCM7(+/-)/MCM7-FLAG, in which one allele of MCM7 is mutated whereas a tetracycline-repressible promoter could manipulate the expression of exogenous MCM7 protein. Overexpressed MCM7 protein supports efficient DNA replication of Epstein-Barr virus oriP and rapid formation of tumors in nude mice without altering the activity of cellular DNA replication. This system provides a unique setting for studying the function of MCM7 and for screening for potential therapeutics for malignant tumors.

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Year:  2003        PMID： 14550576     DOI： 10.1016/s0014-5793(03)01018-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  Mcm4 C-terminal domain of MCM helicase prevents excessive formation of single-stranded DNA at stalled replication forks.

Authors:  Naoki Nitani; Chie Yadani; Hayato Yabuuchi; Hisao Masukata; Takuro Nakagawa
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-27       Impact factor: 11.205

2.  MCM7 and its hosted miR-25, 93 and 106b cluster elicit YAP/TAZ oncogenic activity in lung cancer.

Authors:  Federica Lo Sardo; Mattia Forcato; Andrea Sacconi; Valeria Capaci; Francesca Zanconato; Silvia Di Agostino; Giannino Del Sal; Pier Paolo Pandolfi; Sabrina Strano; Silvio Bicciato; Giovanni Blandino
Journal:  Carcinogenesis       Date:  2016-10-17       Impact factor: 4.944

3.  Exploring the role of miRNAs in renal cell carcinoma progression and metastasis through bioinformatic and experimental analyses.

Authors:  Heba W Z Khella; Nicole M A White; Hala Faragalla; Manal Gabril; Mina Boazak; David Dorian; Bishoy Khalil; Hany Antonios; Tian Tian Bao; Maria D Pasic; R John Honey; Robert Stewart; Kenneth T Pace; Georg A Bjarnason; Michael A S Jewett; George M Yousef
Journal:  Tumour Biol       Date:  2011-11-16

4.  Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays.

Authors:  Robert Grützmann; Christian Pilarsky; Ole Ammerpohl; Jutta Lüttges; Armin Böhme; Bence Sipos; Melanie Foerder; Ingo Alldinger; Beatrix Jahnke; Hans Konrad Schackert; Holger Kalthoff; Bernd Kremer; Günter Klöppel; Hans Detlev Saeger
Journal:  Neoplasia       Date:  2004 Sep-Oct       Impact factor: 5.715

5.  Rbfox2 function in RNA metabolism is impaired in hypoplastic left heart syndrome patient hearts.

Authors:  Sunil K Verma; Vaibhav Deshmukh; Curtis A Nutter; Elizabeth Jaworski; Wenhao Jin; Lalita Wadhwa; Joshua Abata; Marco Ricci; Joy Lincoln; James F Martin; Gene W Yeo; Muge N Kuyumcu-Martinez
Journal:  Sci Rep       Date:  2016-08-03       Impact factor: 4.379

Review 6.  The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy.

Authors:  Yeon-Soo Seo; Young-Hoon Kang
Journal:  Front Mol Biosci       Date:  2018-03-29

Review 7.  YAP and TAZ in Lung Cancer: Oncogenic Role and Clinical Targeting.

Authors:  Federica Lo Sardo; Sabrina Strano; Giovanni Blandino
Journal:  Cancers (Basel)       Date:  2018-05-06       Impact factor: 6.639

8.  In Silico Promoter Analysis can Predict Genes of Functional Relevance in Cell Proliferation: Validation in a Colon Cancer Model.

Authors:  Alan C Moss; Peter P Doran; Padraic Macmathuna
Journal:  Transl Oncogenomics       Date:  2007-02-14
  8 in total

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