Transcription factors controlling the beginning and end of B-cell differentiation.

Powerful techniques--including gene targeting, genomic and proteomic analyses--are allowing a more complete understanding of the transcription factors that drive B-cell development. Regulatory cascades involving multiple steps have been identified at many decision points. In addition, feedback loops and transcriptional inhibition of alternative fates have been found to be important both for commitment to the B lymphocyte lineage and for terminal B-cell differentiation.