Literature DB >> 1454828

Intramolecular DNA triplexes: unusual sequence requirements and influence on DNA polymerization.

A Dayn1, G M Samadashwily, S M Mirkin.   

Abstract

Homopurine-homopyrimidine mirror repeats are known to form intramolecular DNA triplexes in vitro. By probing with chemical agents specific for unusual DNA conformations, we have now demonstrated the formation of intramolecular triplexes consisting of G.G.C and T.A.T base triplets by DNA sequences that are neither homopurine-homopyrimidine nor mirror repeats. This finding significantly enlarges the number of sequences that could form DNA triplexes. The observed triplexes are stable under the conditions that are optimal for DNA polymerases in vitro. We found that triplex formation causes specific termination of DNA polymerization in vitro. This effect is detected for different DNA polymerases and may have implications for the regulation of DNA replication in vivo.

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Year:  1992        PMID： 1454828      PMCID： PMC50559          DOI： 10.1073/pnas.89.23.11406

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

1.  Position and orientation-dependent effects of a eukaryotic Z-triplex DNA motif on episomal DNA replication in COS-7 cells.

Authors:  B T Brinton; M S Caddle; N H Heintz
Journal:  J Biol Chem       Date:  1991-03-15       Impact factor: 5.157

2.  Single strands, triple strands, and kinks in H-DNA.

Authors:  H Htun; J E Dahlberg
Journal:  Science       Date:  1988-09-30       Impact factor: 47.728

Review 3.  The chemistry and biology of unusual DNA structures adopted by oligopurine.oligopyrimidine sequences.

Authors:  R D Wells; D A Collier; J C Hanvey; M Shimizu; F Wohlrab
Journal:  FASEB J       Date:  1988-11       Impact factor: 5.191

4.  Quadruplex structure of Oxytricha telomeric DNA oligonucleotides.

Authors:  F W Smith; J Feigon
Journal:  Nature       Date:  1992-03-12       Impact factor: 49.962

5.  Chemical probing of homopurine-homopyrimidine mirror repeats in supercoiled DNA.

Authors:  O N Voloshin; S M Mirkin; V I Lyamichev; B P Belotserkovskii; M D Frank-Kamenetskii
Journal:  Nature       Date:  1988-06-02       Impact factor: 49.962

6.  Chemical probing of the homopurine.homopyrimidine tract in supercoiled DNA at single-nucleotide resolution.

Authors:  M Vojtísková; S Mirkin; V Lyamichev; O Voloshin; M Frank-Kamenetskii; E Palecek
Journal:  FEBS Lett       Date:  1988-07-18       Impact factor: 4.124

7.  Cationic metal-specific structures adopted by the poly(dG) region and the direct repeats in the chicken adult beta A globin gene promoter.

Authors:  Y Kohwi
Journal:  Nucleic Acids Res       Date:  1989-06-26       Impact factor: 16.971

Review 8.  Topology and formation of triple-stranded H-DNA.

Authors:  H Htun; J E Dahlberg
Journal:  Science       Date:  1989-03-24       Impact factor: 47.728

9.  Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs.

Authors:  E Henderson; C C Hardin; S K Walk; I Tinoco; E H Blackburn
Journal:  Cell       Date:  1987-12-24       Impact factor: 41.582

10.  A pH-dependent structural transition in the homopurine-homopyrimidine tract in superhelical DNA.

Authors:  V I Lyamichev; S M Mirkin; M D Frank-Kamenetskii
Journal:  J Biomol Struct Dyn       Date:  1985-10
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  30 in total

1.  Genome comparison and proteomic characterization of Thermus thermophilus bacteriophages P23-45 and P74-26: siphoviruses with triplex-forming sequences and the longest known tails.

Authors:  Leonid Minakhin; Manisha Goel; Zhanna Berdygulova; Erlan Ramanculov; Laurence Florens; Galina Glazko; Valeri N Karamychev; Alexei I Slesarev; Sergei A Kozyavkin; Igor Khromov; Hans-W Ackermann; Michael Washburn; Arcady Mushegian; Konstantin Severinov
Journal:  J Mol Biol       Date:  2008-02-15       Impact factor: 5.469

Review 2.  Replication fork stalling at natural impediments.

Authors:  Ekaterina V Mirkin; Sergei M Mirkin
Journal:  Microbiol Mol Biol Rev       Date:  2007-03       Impact factor: 11.056

3.  Transcription termination factor TTF-I exhibits contrahelicase activity during DNA replication.

Authors:  Vera Putter; Friedrich Grummt
Journal:  EMBO Rep       Date:  2002-01-29       Impact factor: 8.807

4.  Overcoming a barrier for DNA polymerization in triplex-forming sequences.

Authors:  V N Potaman; J J Bissler
Journal:  Nucleic Acids Res       Date:  1999-08-01       Impact factor: 16.971

5.  Transcription through a simple DNA repeat blocks replication elongation.

Authors:  M M Krasilnikova; G M Samadashwily; A S Krasilnikov; S M Mirkin
Journal:  EMBO J       Date:  1998-09-01       Impact factor: 11.598

6.  Mechanisms of triplex-caused polymerization arrest.

Authors:  A S Krasilnikov; I G Panyutin; G M Samadashwily; R Cox; Y S Lazurkin; S M Mirkin
Journal:  Nucleic Acids Res       Date:  1997-04-01       Impact factor: 16.971

7.  DIR: a novel DNA rearrangement associated with inverted repeats.

Authors:  D J Pinder; C E Blake; D R Leach
Journal:  Nucleic Acids Res       Date:  1997-02-01       Impact factor: 16.971

8.  Precise switching of DNA replication timing in the GC content transition area in the human major histocompatibility complex.

Authors:  T Tenzen; T Yamagata; T Fukagawa; K Sugaya; A Ando; H Inoko; T Gojobori; A Fujiyama; K Okumura; T Ikemura
Journal:  Mol Cell Biol       Date:  1997-07       Impact factor: 4.272

9.  Length-dependent structure formation in Friedreich ataxia (GAA)n*(TTC)n repeats at neutral pH.

Authors:  V N Potaman; E A Oussatcheva; Y L Lyubchenko; L S Shlyakhtenko; S I Bidichandani; T Ashizawa; R R Sinden
Journal:  Nucleic Acids Res       Date:  2004-02-20       Impact factor: 16.971

10.  Uncommon deletions of the Smith-Magenis syndrome region can be recurrent when alternate low-copy repeats act as homologous recombination substrates.

Authors:  Christine J Shaw; Marjorie A Withers; James R Lupski
Journal:  Am J Hum Genet       Date:  2004-05-13       Impact factor: 11.025
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