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Literature DB >> 14531669

Reaching into the major groove of B-DNA: synthesis and nucleic acid binding of a neomycin-hoechst 33258 conjugate.

Abstract

Synthesis of a neomycin-Hoechst 33258 conjugate is reported. The conjugate combines the ligands known to selectively bind in the duplex and the triplex groove. The conjugate stabilizes DNA duplex over DNA triplex. The conjugate selectively stabilizes the DNA duplex (in the presence of salt), with as little as 2 muM of the ligand leading to a DeltaTm of 25 degrees C.

Entities: Chemical Gene

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Year: 2003 PMID： 14531669 DOI： 10.1021/ja036742k

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

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Cited

23 in total

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2. Recognition of HIV-TAR RNA using neomycin-benzimidazole conjugates.

Authors: Nihar Ranjan; Sunil Kumar; Derrick Watkins; Deyun Wang; Daniel H Appella; Dev P Arya
Journal: Bioorg Med Chem Lett Date: 2013-08-14 Impact factor: 2.823

3. Hoechst-IR: an imaging agent that detects necrotic tissue in vivo by binding extracellular DNA.

Authors: Madhuri Dasari; Sungmun Lee; Jay Sy; Dongin Kim; Seungjun Lee; Milton Brown; Michael Davis; Niren Murthy
Journal: Org Lett Date: 2010-08-06 Impact factor: 6.005

4. Utilization of chromic polydiacetylene assemblies as a platform to probe specific binding between drug and RNA.

Authors: Anothai Kamphan; Changjun Gong; Krishnagopal Maiti; Souvik Sur; Rakchart Traiphol; Dev P Arya
Journal: RSC Adv Date: 2017-08-24 Impact factor: 3.361

Review 5. Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities.

Authors: Nishad Thamban Chandrika; Sylvie Garneau-Tsodikova
Journal: Chem Soc Rev Date: 2018-02-19 Impact factor: 54.564

Reaching into the major groove of B-DNA: synthesis and nucleic acid binding of a neomycin-hoechst 33258 conjugate.

1. Click dimers to target HIV TAR RNA conformation.

2. Recognition of HIV-TAR RNA using neomycin-benzimidazole conjugates.

3. Hoechst-IR: an imaging agent that detects necrotic tissue in vivo by binding extracellular DNA.

4. Utilization of chromic polydiacetylene assemblies as a platform to probe specific binding between drug and RNA.

Review 5. Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities.

6. Thermodynamics of nucleic acid "shape readout" by an aminosugar.

7. Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding.

8. New Application of Neomycin B-Bisbenzimidazole Hybrids as Antifungal Agents.

9. Influence of linker length in shape recognition of B* DNA by dimeric aminoglycosides.

10. Synthesis and g-quadruplex-binding properties of defined acridine oligomers.