Literature DB >> 14531033

Antitubercular cassane furanoditerpenoids from the roots of Caesalpinia pulcherrima.

Netnapa Promsawan1, Prasat Kittakoop, Surat Boonphong, Pakawan Nongkunsarn.   

Abstract

Activity-guided fractionation of a root extract of Caesalpinia pulcherrima led to the isolation of two cassane-furanoditerpenoids, 6 beta-benzoyl-7 beta-hydroxyvouacapen-5 alpha-ol (1) and 6 beta-cinnamoyl-7beta-hydroxyvouacapen-5 alpha-ol (2). Compound 2 showed strong antitubercular activity with a minimum inhibitory concentration (MIC) of 6.25 microg/mL, whereas the benzoyl analogue (1) was less active (MIC 25 microg/mL). Both compounds expressed moderate cytotoxic activity towards KB (human oral carcinonoid cancer), BC (human breast cancer) and NCl-H187 (small cell lung cancer) cell lines.

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Year:  2003        PMID： 14531033     DOI： 10.1055/s-2003-42782

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  6 in total

1.  Antiproliferative cassane diterpenoids of Cordyla madagascariensis ssp. madagascariensis from the Madagascar rainforest.

Authors:  Yanpeng Hou; Shugeng Cao; Peggy Brodie; James S Miller; Chris Birkinshaw; Fidisoa Ratovoson; Roland Rakotondrajaona; Rabodo Andriantsiferana; Vincent E Rasamison; David G I Kingston
Journal:  J Nat Prod       Date:  2007-12-29       Impact factor: 4.050

2.  Assessment of phytochemical content, polyphenolic composition, antioxidant and antibacterial activities of Leguminosae medicinal plants in Peninsular Malaysia.

Authors:  Yik Ling Chew; Elaine Wan Ling Chan; Pei Ling Tan; Yau Yan Lim; Johnson Stanslas; Joo Kheng Goh
Journal:  BMC Complement Altern Med       Date:  2011-02-10       Impact factor: 3.659

3.  Absolute configuration of vouaca-pen-5α-ol.

Authors:  Hoong-Kun Fun; Orapun Yodsaoue; Suchada Chantrapromma; Chatchanok Karalai
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-07-31

4.  Absolute configuration of isovouacapenol C.

Authors:  Hoong-Kun Fun; Orapun Yodsaoue; Chatchanok Karalai; Suchada Chantrapromma
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-07-17

5.  Evaluation of antioxidant and free radical scavenging capacities of polyphenolics from pods of Caesalpinia pulcherrima.

Authors:  Feng-Lin Hsu; Wei-Jan Huang; Tzu-Hua Wu; Mei-Hsien Lee; Lih-Chi Chen; Hsiao-Jen Lu; Wen-Chi Hou; Mei-Hsiang Lin
Journal:  Int J Mol Sci       Date:  2012-05-18       Impact factor: 6.208

6.  Crystal structure and Hirshfeld surface analysis of pulcherrin J.

Authors:  K Osahon Ogbeide; J Bodunde Owolabi; Abiodun Falodun; M Iqbal Choudhary; Sammer Yousuf
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-09-29
  6 in total

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