Literature DB >> 14527182

Cannabinoid agonists and antagonists modulate lithium-induced conditioned gaping in rats.

Linda A Parker1, Raphael Mechoulam.   

Abstract

Considerable evidence indicates that conditioned gaping in rats reflects nausea in this species that does not vomit. A series of experiments evaluated the potential of psychoactive cannabinoid agonists, delta-9-THC and HU-210, and non-psychoactive cannabinoids, Cannabidiol (CBD) and its dimethylheptyl homolog (CBD-dmh), to interfere with the establishment and the expression of conditioned gaping in rats. All agents attenuated both the establishment and the expression of conditioned gaping. Furthermore, the CB1 antagonist, SR-141716, reversed the suppressive effect of HU-210 on conditioned gaping. Finally, SR-141716 potentiated lithium-induced conditioned gaping, suggesting that the endogenous cannabinoid system plays a role in the control of nausea.

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Year:  2003        PMID： 14527182     DOI： 10.1007/bf02688831

Source DB:  PubMed          Journal:  Integr Physiol Behav Sci        ISSN： 1053-881X


  42 in total

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Journal:  Eur J Pharmacol       Date:  1998-07-10       Impact factor: 4.432

2.  Cannabimimetic activity in rats and pigeons of HU 210, a potent antiemetic drug.

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Journal:  Pharmacol Biochem Behav       Date:  1999-01       Impact factor: 3.533

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Authors:  L Hanus; S Abu-Lafi; E Fride; A Breuer; Z Vogel; D E Shalev; I Kustanovich; R Mechoulam
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-20       Impact factor: 11.205

4.  Delta-9-tetrahydrocannabinol differentially suppresses cisplatin-induced emesis and indices of motor function via cannabinoid CB(1) receptors in the least shrew.

Authors:  N A Darmani
Journal:  Pharmacol Biochem Behav       Date:  2001 May-Jun       Impact factor: 3.533

5.  Delta(9)-tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB(1) receptor antagonist/inverse agonist SR 141716A.

Authors:  N A Darmani
Journal:  Neuropsychopharmacology       Date:  2001-02       Impact factor: 7.853

6.  Cannabidiol, a non-psychoactive component of cannabis and its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats.

Authors:  Linda A Parker; Raphael Mechoulam; Coralynne Schlievert
Journal:  Neuroreport       Date:  2002-04-16       Impact factor: 1.837

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Authors:  L A Parker; L Brosseau
Journal:  Pharmacol Biochem Behav       Date:  1990-03       Impact factor: 3.533

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Authors:  L E McCarthy; H L Borison
Journal:  Cancer Treat Rep       Date:  1984-02

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Authors:  M L Pelchat; H J Grill; P Rozin; J Jacobs
Journal:  J Comp Psychol       Date:  1983-06       Impact factor: 2.231

10.  The taste reactivity test. I. Mimetic responses to gustatory stimuli in neurologically normal rats.

Authors:  H J Grill; R Norgren
Journal:  Brain Res       Date:  1978-03-24       Impact factor: 3.252
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  16 in total

1.  Effect of combined oral doses of Δ(9)-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea in rat models.

Authors:  Erin M Rock; Cassidy Connolly; Cheryl L Limebeer; Linda A Parker
Journal:  Psychopharmacology (Berl)       Date:  2016-07-20       Impact factor: 4.530

2.  Inverse agonism of cannabinoid CB1 receptors potentiates LiCl-induced nausea in the conditioned gaping model in rats.

Authors:  C L Limebeer; V K Vemuri; H Bedard; S T Lang; K P Ossenkopp; A Makriyannis; L A Parker
Journal:  Br J Pharmacol       Date:  2010-09       Impact factor: 8.739

3.  Tetrahydrocannabinolic acid reduces nausea-induced conditioned gaping in rats and vomiting in Suncus murinus.

Authors:  E M Rock; R L Kopstick; C L Limebeer; L A Parker
Journal:  Br J Pharmacol       Date:  2013-10       Impact factor: 8.739

4.  Evaluation of the potential of the phytocannabinoids, cannabidivarin (CBDV) and Δ(9) -tetrahydrocannabivarin (THCV), to produce CB1 receptor inverse agonism symptoms of nausea in rats.

Authors:  Erin M Rock; Martin A Sticht; Marnie Duncan; Colin Stott; Linda A Parker
Journal:  Br J Pharmacol       Date:  2013-10       Impact factor: 8.739

5.  The cannabinoid CB1 antagonist AM 251 produces food avoidance and behaviors associated with nausea but does not impair feeding efficiency in rats.

Authors:  P J McLaughlin; K M Winston; C L Limebeer; L A Parker; A Makriyannis; J D Salamone
Journal:  Psychopharmacology (Berl)       Date:  2005-03-15       Impact factor: 4.530

6.  The effect of cannabidiol and URB597 on conditioned gaping (a model of nausea) elicited by a lithium-paired context in the rat.

Authors:  Erin M Rock; Cheryl L Limebeer; Raphael Mechoulam; Daniele Piomelli; Linda A Parker
Journal:  Psychopharmacology (Berl)       Date:  2007-11-09       Impact factor: 4.530

7.  Effect of combined doses of Δ(9)-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea using rat (Sprague- Dawley) models of conditioned gaping.

Authors:  Erin M Rock; Cheryl L Limebeer; Linda A Parker
Journal:  Psychopharmacology (Berl)       Date:  2015-09-18       Impact factor: 4.530

8.  Effect of selective inhibition of monoacylglycerol lipase (MAGL) on acute nausea, anticipatory nausea, and vomiting in rats and Suncus murinus.

Authors:  Linda A Parker; Micah J Niphakis; Rachel Downey; Cheryl L Limebeer; Erin M Rock; Martin A Sticht; Heather Morris; Rehab A Abdullah; Aron H Lichtman; Benjamin F Cravatt
Journal:  Psychopharmacology (Berl)       Date:  2014-08-03       Impact factor: 4.530

9.  Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex.

Authors:  Martin A Sticht; Cheryl L Limebeer; Benjamin R Rafla; Rehab A Abdullah; Justin L Poklis; Winnie Ho; Micah J Niphakis; Benjamin F Cravatt; Keith A Sharkey; Aron H Lichtman; Linda A Parker
Journal:  Neuropharmacology       Date:  2015-11-02       Impact factor: 5.250

10.  Effect of combined doses of Δ9-tetrahydrocannabinol and cannabidiol or tetrahydrocannabinolic acid and cannabidiolic acid on acute nausea in male Sprague-Dawley rats.

Authors:  Erin M Rock; Megan T Sullivan; Sarah Pravato; Mick Pratt; Cheryl L Limebeer; Linda A Parker
Journal:  Psychopharmacology (Berl)       Date:  2020-01-02       Impact factor: 4.530
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