Literature DB >> 1451808

'All-or-none' mechanism of the molten globule unfolding.

V N Uversky1, G V Semisotnov, R H Pain, O B Ptitsyn.   

Abstract

The Gdm-HCl-induced unfolding of bovine carbonic anhydrase B and S. aureus beta-lactamase was studied at 4 degrees C by a variety of methods. With the use of FPLC it has been shown that within the transition from the molten globule to the unfolded state the distribution function of molecular dimensions is bimodal. This means that equilibrium intermediates between the molten globule and the unfolded states are absent, i.e. the molten globule unfolding follows the 'all-or-none' mechanism.

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Year:  1992        PMID： 1451808     DOI： 10.1016/0014-5793(92)81468-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  15 in total

1.  The Effect of pH on Globular State of Lipase-3646; an Appropriate Model for Molten Globule Investigations.

Authors:  Bahram Pooreydy Golaki; Saeed Aminzadeh; Ali Asghar Karkhane; Bagher Yakhchali; Parisa Farrokh; Ferdous Rastgar Jazii; Mohammadsadegh Nadimifar
Journal:  Protein J       Date:  2015-08       Impact factor: 2.371

2.  Circularly permuted dihydrofolate reductase possesses all the properties of the molten globule state, but can resume functional tertiary structure by interaction with its ligands.

Authors:  V N Uversky; V P Kutyshenko; V V Rogov; K S Vassilenko; A T Gudkov
Journal:  Protein Sci       Date:  1996-09       Impact factor: 6.725

3.  Activation of chicken liver dihydrofolate reductase by urea and guanidine hydrochloride is accompanied by conformational change at the active site.

Authors:  Y X Fan; M Ju; J M Zhou; C L Tsou
Journal:  Biochem J       Date:  1996-04-01       Impact factor: 3.857

4.  Unfolding of CPR3 Gets Initiated at the Active Site and Proceeds via Two Intermediates.

Authors:  Vaibhav Kumar Shukla; Jai Shankar Singh; Neha Vispute; Basir Ahmad; Ashutosh Kumar; Ramakrishna V Hosur
Journal:  Biophys J       Date:  2017-02-28       Impact factor: 4.033

5.  Potato virus A genome-linked protein VPg is an intrinsically disordered molten globule-like protein with a hydrophobic core.

Authors:  Kimmo I Rantalainen; Vladimir N Uversky; Perttu Permi; Nisse Kalkkinen; A Keith Dunker; Kristiina Mäkinen
Journal:  Virology       Date:  2008-06-03       Impact factor: 3.616

6.  Inactivation during denaturation of ribonuclease A by guanidinium chloride is accompanied by unfolding at the active site.

Authors:  H J Yang; C L Tsou
Journal:  Biochem J       Date:  1995-01-15       Impact factor: 3.857

7.  Structural and Biophysical Characterization of Rab5a from Leishmania Donovani.

Authors:  Diva Maheshwari; Rahul Yadav; Ruchir Rastogi; Anupam Jain; Sarita Tripathi; Amitabha Mukhopadhyay; Ashish Arora
Journal:  Biophys J       Date:  2018-08-30       Impact factor: 4.033

8.  Equilibrium partially folded states of B. licheniformis[Formula: see text]-lactamase.

Authors:  Valeria A Risso; Mario R Ermácora
Journal:  Eur Biophys J       Date:  2019-03-30       Impact factor: 1.733

9.  Heterogeneity of equilibrium molten globule state of cytochrome c induced by weak salt denaturants under physiological condition.

Authors:  Hamidur Rahaman; Md Khurshid Alam Khan; Md Imtaiyaz Hassan; Asimul Islam; Ali Akbar Moosavi-Movahedi; Faizan Ahmad
Journal:  PLoS One       Date:  2015-04-07       Impact factor: 3.240

10.  A superior drug carrier--aponeocarzinostatin in partially unfolded state fully protects the labile antitumor enediyne.

Authors:  Aranganathan Shanmuganathan; Thallapuranam Krishnaswamy Suresh Kumar; Chiy-Mey Huang; Chin Yu; Der-Hang Chin
Journal:  J Biomed Sci       Date:  2009-05-23       Impact factor: 8.410
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