Literature DB >> 145179

Dosage effects for superoxide dismutase-1 in nucleated cells aneuploid for chromosome 21.

W W Feaster, L W Kwok, C J Epstein.   

Abstract

Assays of the activity of chromosome 21 determined superoxide dismutase-1 (SOD-1) in lymphocytes and polymorphonuclear granulocytes have demonstrated 38% and 40% increases, respectively, in cells from individuals with trisomy 21. Similarly, SOD-1 activity in trisomic fibroblasts is increased by 81%, while cells monosomic for chromosome 21 have only 60% of normal activity. Taken together with the data on SOD-1 activities in trisomic erythrocytes and platelets, the present results firmly confirm the existence of a true dosage effect for this enzyme in cells aneuploid for chromosome 21. However, the results of assays of the activity of glutathione peroxidase in trisomic fibroblasts did not confirm the possibility previously reported of a chromosome 21 related dosage effect for this enzyme.

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Year:  1977        PMID： 145179      PMCID： PMC1685525     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  29 in total

1.  Improved HL-A typing of cadaveric renal donors. I. Quantitation of HL-A gene dosage.

Authors:  L Dumble; P J Morris
Journal:  Tissue Antigens       Date:  1975-04

2.  Antibodies to a cell-surface component coded by human chromosome 21 inhibit action of interferon.

Authors:  M Revel; D Bash; F H Ruddle
Journal:  Nature       Date:  1976-03-11       Impact factor: 49.962

3.  Dosage effect of SOD-A gene in 21-trisomic cells.

Authors:  N Crosti; A Serra; A Rigo; P Viglino
Journal:  Hum Genet       Date:  1976-02-29       Impact factor: 4.132

4.  Superoxide dismutase activities of blood platelets in trisomy 21.

Authors:  P M Sinet; F Lavelle; A M Michelson; H Jerome
Journal:  Biochem Biophys Res Commun       Date:  1975-12-01       Impact factor: 3.575

5.  Increase in glutathione peroxidase activity in erythrocytes from trisomy 21 subjects.

Authors:  P M Sinet; A M Michelson; A Bazin; J Lejeune; H Jerome
Journal:  Biochem Biophys Res Commun       Date:  1975-12-01       Impact factor: 3.575

6.  Gene dosage effect in human trisomy 16.

Authors:  B Marimo; F Giannelli
Journal:  Nature       Date:  1975-07-17       Impact factor: 49.962

7.  Gene dosage: evidence for assignment of erythrocyte acid phosphatase locus to chromosome 2.

Authors:  R E Magenis; R D Koler; E Lovrien; R H Bigley; M C DuVal; K M Overton
Journal:  Proc Natl Acad Sci U S A       Date:  1975-11       Impact factor: 11.205

8.  The estimation of red cell superoxide dismutase activity by pulse radiolysis in normal and trisomic 21 subjects.

Authors:  L Gilles; C Ferradini; J Foos; J Pucheault; D Allard; P M Sinet; H Jerome
Journal:  FEBS Lett       Date:  1976-10-15       Impact factor: 4.124

9.  Expression of H-Y antigen in human males with two Y chromosomes.

Authors:  S S Wachtel; G C Koo; W R Breg; S Elias; E A Boyse; O J Miller
Journal:  N Engl J Med       Date:  1975-11-20       Impact factor: 91.245

10.  [Trisomy 21 and superoxide dismutase-1 (IPO-A). Tentative localization of sub-band 21Q22.1].

Authors:  P M Sinet; J Couturier; B Dutrillaux; M Poissonnier; O Raoul; M O Rethore; D Allard; J Lejeune; H Jerome
Journal:  Exp Cell Res       Date:  1976-01       Impact factor: 3.905
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  27 in total

1.  Down syndrome: gene dosage at the transcriptional level in skin fibroblasts.

Authors:  D M Kurnit
Journal:  Proc Natl Acad Sci U S A       Date:  1979-05       Impact factor: 11.205

2.  Analysis of gene-dosage effects on the expression of CD18 by trisomy 21 lymphoblastoid cell-lines using a statistical model to fit flow cytometry profiles.

Authors:  W G Bardsley; B P McMurray; A Robson; S D'Souza; G M Taylor
Journal:  Hum Genet       Date:  1990-12       Impact factor: 4.132

3.  Regional localization of DNA sequences on chromosome 21 using somatic cell hybrids.

Authors:  M L Van Keuren; P C Watkins; H A Drabkin; E W Jabs; J F Gusella; D Patterson
Journal:  Am J Hum Genet       Date:  1986-06       Impact factor: 11.025

4.  Two-dimensional gel analysis of proteins from human trisomy 21 fetal liver tissue after DEAE-Sepharose chromatography.

Authors:  G H Reichert
Journal:  Hum Genet       Date:  1986-07       Impact factor: 4.132

5.  Blood trace element analyses fail to predict diagnosis.

Authors:  C H Zuckerman; T F Massaro
Journal:  J Autism Dev Disord       Date:  1986-06

6.  Alterations in the relative amounts of specific mRNA species in the developing human brain in Down's syndrome.

Authors:  S A Whatley; C Hall; A N Davison; L Lim
Journal:  Biochem J       Date:  1984-05-15       Impact factor: 3.857

7.  Nucleotide sequence and expression of human chromosome 21-encoded superoxide dismutase mRNA.

Authors:  L Sherman; N Dafni; J Lieman-Hurwitz; Y Groner
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

8.  Role of superoxide anion in host cell injury induced by mycoplasma pneumoniae infection. A study in normal and trisomy 21 cells.

Authors:  M Almagor; I Kahane; S Yatziv
Journal:  J Clin Invest       Date:  1984-03       Impact factor: 14.808

9.  The contribution of the citrate pathway to oxidative stress in Down syndrome.

Authors:  Paolo Convertini; Alessio Menga; Generoso Andria; Iris Scala; Anna Santarsiero; Maria A Castiglione Morelli; Vito Iacobazzi; Vittoria Infantino
Journal:  Immunology       Date:  2016-10-03       Impact factor: 7.397

Review 10.  Molecular genetics of human chromosome 21.

Authors:  P C Watkins; R E Tanzi; S V Cheng; J F Gusella
Journal:  J Med Genet       Date:  1987-05       Impact factor: 6.318
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