Literature DB >> 14511933

Telomere maintenance and disease.

Judy M Y Wong1, Kathleen Collins.   

Abstract

The proliferative capacity of human cells is regulated by telomerase, an enzyme uniquely specialised for telomeric DNA synthesis. The critical role of telomerase activation in tumour progression and tumour maintenance has been well established in studies of cancer and of oncogenic transformation in cell culture. New evidence suggests that telomerase activation has an important role in normal somatic cells, and that failure to activate sufficient telomerase also promotes disease. We review the evidence for premature telomere attrition in proliferative deficiencies of the human haemopoietic system, and discuss the potential use of telomerase activation in telomere-restorative gene therapy.

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Year:  2003        PMID： 14511933     DOI： 10.1016/S0140-6736(03)14369-3

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  104 in total

1.  Exploring potential sources of differential vulnerability and susceptibility in risk from environmental hazards to expand the scope of risk assessment.

Authors:  Joel Schwartz; David Bellinger; Thomas Glass
Journal:  Am J Public Health       Date:  2011-10-20       Impact factor: 9.308

2.  Race-related health disparities and biological aging: does rate of telomere shortening differ across blacks and whites?

Authors:  Marissa Rewak; Stephen Buka; Jennifer Prescott; Immaculata De Vivo; Eric B Loucks; Ichiro Kawachi; Amy L Non; Laura D Kubzansky
Journal:  Biol Psychol       Date:  2014-03-29       Impact factor: 3.251

3.  A telomerase holoenzyme protein enhances telomerase RNA assembly with telomerase reverse transcriptase.

Authors:  Ramadevi Prathapam; Keren L Witkin; Catherine M O'Connor; Kathleen Collins
Journal:  Nat Struct Mol Biol       Date:  2005-02-06       Impact factor: 15.369

4.  Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres.

Authors:  Beáta E Jády; Patricia Richard; Edouard Bertrand; Tamás Kiss
Journal:  Mol Biol Cell       Date:  2005-11-30       Impact factor: 4.138

Review 5.  The biogenesis and regulation of telomerase holoenzymes.

Authors:  Kathleen Collins
Journal:  Nat Rev Mol Cell Biol       Date:  2006-07       Impact factor: 94.444

6.  Stepwise protein-mediated RNA folding directs assembly of telomerase ribonucleoprotein.

Authors:  Michael D Stone; Mariana Mihalusova; Catherine M O'connor; Ramadevi Prathapam; Kathleen Collins; Xiaowei Zhuang
Journal:  Nature       Date:  2007-02-25       Impact factor: 49.962

7.  Leukocyte telomere length and mortality in the Cardiovascular Health Study.

Authors:  Annette L Fitzpatrick; Richard A Kronmal; Masayuki Kimura; Jeffrey P Gardner; Bruce M Psaty; Nancy S Jenny; Russell P Tracy; Sheetal Hardikar; Abraham Aviv
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2011-02-02       Impact factor: 6.053

8.  Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation.

Authors:  Dragony Fu; Kathleen Collins
Journal:  Mol Cell       Date:  2007-12-14       Impact factor: 17.970

9.  A prospective study of telomere length and the risk of skin cancer.

Authors:  Jiali Han; Abrar A Qureshi; Jennifer Prescott; Qun Guo; Li Ye; David J Hunter; Immaculata De Vivo
Journal:  J Invest Dermatol       Date:  2008-07-31       Impact factor: 8.551

10.  Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease.

Authors:  Ramin Farzaneh-Far; Jue Lin; Elissa S Epel; William S Harris; Elizabeth H Blackburn; Mary A Whooley
Journal:  JAMA       Date:  2010-01-20       Impact factor: 56.272
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