| Literature DB >> 14510581 |
Su-Dong Cho1, Yong-Dae Park, Jeum-Jong Kim, Sang-Gyeong Lee, Chen Ma, Sang-Yong Song, Woo-Hong Joo, J R Falck, Motoo Shiro, Dong-Soo Shin, Yong-Jin Yoon.
Abstract
Pyrido[2,3-b][1,4]oxazin-2-ones are conveniently prepared in excellent yields by a one-pot annulation of N-substituted-2-chloroacetamides with 2-halo-3-hydroxypyridines with use of cesium carbonate in refluxing acetonitrile. The key transformation features a Smiles rearrangement of the initial O-alkylation product and subsequent cyclization.Entities:
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Year: 2003 PMID： 14510581 DOI： 10.1021/jo034593i
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354