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Literature DB >> 14507224

Novel multicomponent reaction for the combinatorial synthesis of 2-imidazolines.

Robin S Bon¹, Chongen Hong, Marinus J Bouma, Rob F Schmitz, Frans J J de Kanter, Martin Lutz, Anthony L Spek, Romano V A Orru.

Abstract

[reaction: see text] The three-component condensation between an amine, an aldehyde, and an alpha-acidic isocyanide efficiently provides substituted 2-imidazolines in a one-pot reaction under mild conditions.

Entities: Chemical

Year: 2003 PMID： 14507224 DOI： 10.1021/ol035521g

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

6 in total

Review 1. Chemistry and biology of multicomponent reactions.

Authors: Alexander Dömling; Wei Wang; Kan Wang
Journal: Chem Rev Date: 2012-03-22 Impact factor: 60.622

2. Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists.

Authors: Anna Czarna; Barbara Beck; Stuti Srivastava; Grzegorz M Popowicz; Siglinde Wolf; Yijun Huang; Michal Bista; Tad A Holak; Alexander Dömling
Journal: Angew Chem Int Ed Engl Date: 2010-07-19 Impact factor: 15.336

Novel multicomponent reaction for the combinatorial synthesis of 2-imidazolines.

Review 1. Chemistry and biology of multicomponent reactions.

2. Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists.

3. A Van Leusen deprotection-cyclization strategy as a fast entry into two imidazoquinoxaline families.

4. Rapid and efficient hydrophilicity tuning of p53/mdm2 antagonists.

Review 5. Silver and gold-catalyzed multicomponent reactions.

6. Finding Furfural Hydrogenation Catalysts via Predictive Modelling.