Literature DB >> 14506047

Recombination proficiency influences frequency and locus of mutational resistance to linezolid in Enterococcus faecalis.

Michael Lobritz1, Rebecca Hutton-Thomas, Steve Marshall, Louis B Rice.   

Abstract

In vitro linezolid resistance was selected at a higher frequency in Enterococcus faecalis JH2-2 than in recombination-deficient E. faecalis UV202. Resistance in JH2-2 was related to accumulated G2576T mutations in 23S rRNA genes, with the least resistance conferred by mutations in two of four copies. UV202 resistance was associated with a G2505A mutation present in a single copy in mutants with different MICs.

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Year:  2003        PMID： 14506047      PMCID： PMC201147          DOI： 10.1128/AAC.47.10.3318-3320.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid.

Authors:  R D Gonzales; P C Schreckenberger; M B Graham; S Kelkar; K DenBesten; J P Quinn
Journal:  Lancet       Date:  2001-04-14       Impact factor: 79.321

2.  Risk factors associated with the development of infection with linezolid- and vancomycin-resistant Enterococcus faecium.

Authors:  Manjunath P Pai; Keith A Rodvold; Paul C Schreckenberger; Ronald D Gonzales; Jennifer M Petrolatti; John P Quinn
Journal:  Clin Infect Dis       Date:  2002-10-28       Impact factor: 9.079

3.  Resistance to linezolid: characterization of mutations in rRNA and comparison of their occurrences in vancomycin-resistant enterococci.

Authors:  J Prystowsky; F Siddiqui; J Chosay; D L Shinabarger; J Millichap; L R Peterson; G A Noskin
Journal:  Antimicrob Agents Chemother       Date:  2001-07       Impact factor: 5.191

4.  Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center.

Authors:  P Kloss; L Xiong; D L Shinabarger; A S Mankin
Journal:  J Mol Biol       Date:  1999-11-19       Impact factor: 5.469

5.  Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action.

Authors:  L Xiong; P Kloss; S Douthwaite; N M Andersen; S Swaney; D L Shinabarger; A S Mankin
Journal:  J Bacteriol       Date:  2000-10       Impact factor: 3.490

6.  RecA-Mediated gene conversion and aminoglycoside resistance in strains heterozygous for rRNA.

Authors:  T Prammananan; P Sander; B Springer; E C Böttger
Journal:  Antimicrob Agents Chemother       Date:  1999-03       Impact factor: 5.191

7.  Evernimicin (SCH27899) inhibits a novel ribosome target site: analysis of 23S ribosomal DNA mutants.

Authors:  P V Adrian; C Mendrick; D Loebenberg; P McNicholas; K J Shaw; K P Klugman; R S Hare; T A Black
Journal:  Antimicrob Agents Chemother       Date:  2000-11       Impact factor: 5.191

8.  Oxazolidinone antibiotics target the P site on Escherichia coli ribosomes.

Authors:  Hiroyuki Aoki; Lizhu Ke; Susan M Poppe; Toni J Poel; Elizabeth A Weaver; Robert C Gadwood; Richard C Thomas; Dean L Shinabarger; M Clelia Ganoza
Journal:  Antimicrob Agents Chemother       Date:  2002-04       Impact factor: 5.191

9.  Linezolid resistance in Staphylococcus aureus: characterization and stability of resistant phenotype.

Authors:  Satish K Pillai; George Sakoulas; Christine Wennersten; George M Eliopoulos; Robert C Moellering; Mary Jane Ferraro; Howard S Gold
Journal:  J Infect Dis       Date:  2002-11-04       Impact factor: 5.226

10.  Conjugal transfer of plasmid-borne multiple antibiotic resistance in Streptococcus faecalis var. zymogenes.

Authors:  A E Jacob; S J Hobbs
Journal:  J Bacteriol       Date:  1974-02       Impact factor: 3.490
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  21 in total

Review 1.  Resistance to linezolid caused by modifications at its binding site on the ribosome.

Authors:  Katherine S Long; Birte Vester
Journal:  Antimicrob Agents Chemother       Date:  2011-12-05       Impact factor: 5.191

2.  Clinical-use-associated decrease in susceptibility of vancomycin-resistant Enterococcus faecium to linezolid: a comparison with quinupristin-dalfopristin.

Authors:  Issam I Raad; Hend A Hanna; Ray Y Hachem; Tanya Dvorak; Rebecca B Arbuckle; Gassan Chaiban; Louis B Rice
Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191

3.  Molecular detection of linezolid resistance in Enterococcus faecium and Enterococcus faecalis by use of 5' nuclease real-time PCR compared to a modified classical approach.

Authors:  Guido Werner; Birgit Strommenger; Ingo Klare; Wolfgang Witte
Journal:  J Clin Microbiol       Date:  2004-11       Impact factor: 5.948

4.  Heterogeneous macrolide resistance and gene conversion in the pneumococcus.

Authors:  Nicole Wolter; Anthony M Smith; David J Farrell; Keith P Klugman
Journal:  Antimicrob Agents Chemother       Date:  2006-01       Impact factor: 5.191

5.  Detection of mutations conferring resistance to linezolid in Enterococcus spp. by fluorescence in situ hybridization.

Authors:  Guido Werner; Melanie Bartel; Nele Wellinghausen; Andreas Essig; Ingo Klare; Wolfgang Witte; Sven Poppert
Journal:  J Clin Microbiol       Date:  2007-05-02       Impact factor: 5.948

6.  Influence of recombination on development of mutational resistance to linezolid in Enterococcus faecalis JH2-2.

Authors:  Leyla Boumghar-Bourtchaï; Anne Dhalluin; Brigitte Malbruny; Sébastien Galopin; Roland Leclercq
Journal:  Antimicrob Agents Chemother       Date:  2009-06-22       Impact factor: 5.191

7.  Increasing incidence of linezolid-intermediate or -resistant, vancomycin-resistant Enterococcus faecium strains parallels increasing linezolid consumption.

Authors:  Marc H Scheetz; Stephanie A Knechtel; Michael Malczynski; Michael J Postelnick; Chao Qi
Journal:  Antimicrob Agents Chemother       Date:  2008-04-07       Impact factor: 5.191

8.  In vitro activity of linezolid against key gram-positive organisms isolated in the united states: results of the LEADER 2004 surveillance program.

Authors:  Deborah C Draghi; Daniel J Sheehan; Patricia Hogan; Daniel F Sahm
Journal:  Antimicrob Agents Chemother       Date:  2005-12       Impact factor: 5.191

Review 9.  The rise of the Enterococcus: beyond vancomycin resistance.

Authors:  Cesar A Arias; Barbara E Murray
Journal:  Nat Rev Microbiol       Date:  2012-03-16       Impact factor: 60.633

10.  Molecular analysis of linezolid resistance in clinical Enterococcus faecium isolates by polymerase chain reaction and pyrosequencing.

Authors:  P Schnitzler; K Schulz; C Lampson; M Geiss; H K Geiss
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2010-09-03       Impact factor: 3.267
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