Literature DB >> 14505657

Synthesis and biological evaluation of thymine nucleosides fused with 3',4'-tetrahydrofuran ring.

Myong Jung Kim1, Hea Ok Kim, Hee-Doo Kim, Joong Hyup Kim, Lak Shin Jeong, Moon Woo Chun.   

Abstract

The pyrimidine nucleosides fused with 3',4'-tetrahydrofuran ring were successfully synthesized, starting from 1,2;5,6-di-O-isopropylidene-D-glucose and assayed for antiviral activities against HIV-1, HIV-2, EMCV, Cox. B3 and VSV. Thymine analogue (5) and its corresponding 2'-deoxy analogue (6) exhibited high cytotoxicity instead of giving antiviral activities.

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Year:  2003        PMID： 14505657     DOI： 10.1016/s0960-894x(03)00730-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Synthesis of 3'-acetamidoadenosine derivatives as potential A3 adenosine receptor agonists.

Authors:  Moon Woo Chun; Sung Wook Choi; Tae Kyung Kang; Won Jun Choi; Hea Ok Kim; Zhan-Guo Gao; Kenneth A Jacobson; Lak Shin Jeong
Journal:  Nucleosides Nucleotides Nucleic Acids       Date:  2008-04       Impact factor: 1.381

2.  Synthesis and biological evaluation of 2',4'- and 3',4'-bridged nucleoside analogues.

Authors:  K C Nicolaou; Shelby P Ellery; Fatima Rivas; Karen Saye; Eric Rogers; Tyler J Workinger; Mark Schallenberger; Rommel Tawatao; Ana Montero; Ann Hessell; Floyd Romesberg; Dennis Carson; Dennis Burton
Journal:  Bioorg Med Chem       Date:  2011-07-23       Impact factor: 3.641
  2 in total

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