| Literature DB >> 14505387 |
Sonya M Khersonsky1, Da-Woon Jung, Tae-Wook Kang, Daniel P Walsh, Ho-Sang Moon, Hakryul Jo, Eric M Jacobson, Vivekananda Shetty, Thomas A Neubert, Young-Tae Chang.
Abstract
An improved forward chemical genetics approach was successfully demonstrated using a tagged library concept. A small-molecule triazine library with linkers was used to screen for brain/eye developmental phenotypes in a zebrafish embryo system. This approach enabled the rapid isolation of the target proteins by facile affinity matrix preparation and elucidated the first small-molecule inhibitors for several ribosomal accessory proteins or their complex as the target.Entities:
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Year: 2003 PMID： 14505387 DOI： 10.1021/ja035334d
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419