A Absalom1, D Amutike, A Lal, M White, G N C Kenny. 1. University Department of Anaesthesia, Glasgow Royal Infirmary, Queen Elizabeth Building, Alexandra Parade, Glasgow G31 2ER, UK. anthony.absalom@nnuh.nhs.uk
Abstract
BACKGROUND: A prototype paediatric propofol target-controlled infusion (TCI) system, the 'Paedfusor' has been developed. This system incorporates a paediatric pharmacokinetic data set and algorithm specific for children in a Graseby 3500 anaesthesia syringe driver. In this study we have evaluated the accuracy of the Paedfusor TCI system in children who underwent either cardiac surgery or cardiac catheterization procedures. METHODS: Twenty-nine children aged 1-15 yr were investigated. General anaesthesia was provided using propofol administered by the Paedfusor system. Accuracy of the system was evaluated by obtaining up to 9 arterial samples for measurement of propofol concentration both during anaesthesia and in the recovery period. Measured arterial propofol concentrations were then compared with values calculated by the Paedfusor. RESULTS: The predictive indices of median performance error (MDPE), and median absolute performance error (MDAPE) of the Paedfusor system were found to be 4.1% and 9.7%, respectively and the median value for wobble was 8.3%. These values are much better than those found with the adult 'Diprifusor' system. CONCLUSION: The Paedfusor performance was found to be within the accepted limits for use as a TCI system.
BACKGROUND: A prototype paediatric propofol target-controlled infusion (TCI) system, the 'Paedfusor' has been developed. This system incorporates a paediatric pharmacokinetic data set and algorithm specific for children in a Graseby 3500 anaesthesia syringe driver. In this study we have evaluated the accuracy of the Paedfusor TCI system in children who underwent either cardiac surgery or cardiac catheterization procedures. METHODS: Twenty-nine children aged 1-15 yr were investigated. General anaesthesia was provided using propofol administered by the Paedfusor system. Accuracy of the system was evaluated by obtaining up to 9 arterial samples for measurement of propofol concentration both during anaesthesia and in the recovery period. Measured arterial propofol concentrations were then compared with values calculated by the Paedfusor. RESULTS: The predictive indices of median performance error (MDPE), and median absolute performance error (MDAPE) of the Paedfusor system were found to be 4.1% and 9.7%, respectively and the median value for wobble was 8.3%. These values are much better than those found with the adult 'Diprifusor' system. CONCLUSION: The Paedfusor performance was found to be within the accepted limits for use as a TCI system.
Authors: Chris J Brouse; Walter Karlen; Guy A Dumont; Dorothy Myers; Erin Cooke; Jonathan Stinson; Joanne Lim; J Mark Ansermino Journal: J Clin Monit Comput Date: 2013-04-09 Impact factor: 2.502
Authors: Enno D Wildschut; Annewil van Saet; Pavla Pokorna; Maurice J Ahsman; John N Van den Anker; Dick Tibboel Journal: Pediatr Clin North Am Date: 2012-08-29 Impact factor: 3.278