Literature DB >> 14502553

Physicochemical properties of sildenafil citrate (Viagra) and sildenafil base.

Petr Melnikov1, Pedro P Corbi, Alexandre Cuin, Mauricio Cavicchioli, Wellington R Guimarães.   

Abstract

Sildenafil citrate (Viagra) [I] and sildenafil base [II] are easily and unequivocally characterized by a set of physicochemical methods that include X-ray diffractometry, infrared spectroscopy, and thermal analysis. Monoclinic lattice constants: [I]: a = 26.98 A; b = 11.95 A; c = 16.68 A; beta = 106.97 degrees. [II]: a = 8.66 A; b = 34.27 A; c = 8.93 A; beta = 96.63 degrees. Both compounds decompose at 189.4 degrees C [I] and 251.9 degrees C [II]. Densities and refractive indices are given. Copyright 2003 Wiley-Liss, Inc. and the American Pharmacists Association

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Year:  2003        PMID： 14502553     DOI： 10.1002/jps.10469

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  4 in total

1.  The effects of screw configuration and polymeric carriers on hot-melt extruded taste-masked formulations incorporated into orally disintegrating tablets.

Authors:  Joseph T Morott; Manjeet Pimparade; Jun-Bom Park; Chelsea P Worley; Soumyajit Majumdar; Zhuoyang Lian; Elanor Pinto; Yunxia Bi; Thomas Durig; Michael A Repka
Journal:  J Pharm Sci       Date:  2014-11-19       Impact factor: 3.534

2.  Self-nanoemulsifying formulation for oral delivery of sildenafil: effect on physicochemical attributes and in vivo pharmacokinetics.

Authors:  Sanyog Jain; Narinder Kumar; Reena Sharma; Rohan Ghadi; Tushar Date; Nallamothu Bhargavi; Dasharath Chaudhari; Sameer S Katiyar
Journal:  Drug Deliv Transl Res       Date:  2022-10-12       Impact factor: 5.671

3.  A nanohybrid system for taste masking of sildenafil.

Authors:  Ji-Hee Lee; Goeun Choi; Yeon-Ji Oh; Je Won Park; Young Bin Choy; Mung Chul Park; Yeo Joon Yoon; Hwa Jeong Lee; Hee Chul Chang; Jin-Ho Choy
Journal:  Int J Nanomedicine       Date:  2012-03-26

Review 4.  Sildenafil 4.0-Integrated Synthetic Chemistry, Formulation and Analytical Strategies Effecting Immense Therapeutic and Societal Impact in the Fourth Industrial Era.

Authors:  Andreas Ouranidis; Anastasia Tsiaxerli; Elisavet Vardaka; Catherine K Markopoulou; Constantinos K Zacharis; Ioannis Nicolaou; Dimitris Hatzichristou; Anna-Bettina Haidich; Nikolaos Kostomitsopoulos; Kyriakos Kachrimanis
Journal:  Pharmaceuticals (Basel)       Date:  2021-04-15
  4 in total

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