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Literature DB >> 14480419

A study of possible mediators of inflammatory reactions in the mouse foot.

Abstract

A number of compounds have been studied for their ability to antagonize the inflammatory reaction produced by injections of formaldehyde and 5-hydroxytryptamine in the mouse foot. An attempt has been made to elucidate the ways in which certain hydroxybenzoates, pyrazolones, sympathomimetic amines, flavone and flavanone glycosides, local anaesthetics, antihistamines and anti-5-hydroxytryptamine substances produce their anti-inflammatory effect.

Entities: Chemical Species

Keywords: ANESTHETICS, LOCAL/pharmacology; ANTIHISTAMINICS/pharmacology; BENZOATES/pharmacology; FLAVONES/pharmacology; FORMALDEHYDE/pharmacology; HETEROCYCLIC COMPOUNDS/pharmacology; INFLAMMATION/experimental; SEROTONIN/pharmacology; SYMPATHOMIMETICS/pharmacology

Mesh：

Substances：

Year: 1962 PMID： 14480419 PMCID： PMC1482121 DOI： 10.1111/j.1476-5381.1962.tb01415.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

16 in total

4. The demonstration of the role of mediators in turpentine pleurisy in rats by experimental suppression of the inflammatory changes.

Authors: W G SPECTOR; D A WILLOUGHBY
Journal: J Pathol Bacteriol Date: 1959-01

A study of possible mediators of inflammatory reactions in the mouse foot.

1. Analgesic and antipyretic properties of some aspirin derivatives.

2. 5-hydroxytryptamine antagonists.

3. Analgesic-antipyretic drugs as inhibitors of kallikrein.

4. The demonstration of the role of mediators in turpentine pleurisy in rats by experimental suppression of the inflammatory changes.

5. Substances which affect capillary permeability.

6. The action of sympathomimetic amines in animals treated with reserpine.

7. Release of 5-hydroxytryptamine and histamine from tissues of the rat.

8. A possible basis for the anti-inflammatory activity of salicylates and other non-hormonal anti-rheumatic drugs.

9. Action of salicylates and related drugs on inflammation.

10. Some inhibitors of histamine-induced and formaldehyde-induced inflammation in mice.

1. The anti-inflammatory action of nepitrin, a flavonoid.

2. [The effect of cyclophosphamide (Endoxan) on acute and chronic inflammation in the guinea pig].

3. Histamine mediates the pro-inflammatory effect of latex of Calotropis procera in rats.