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Literature DB >> 1445193

A positive regulator of the ribosomal protein gene, beta factor, belongs to the ETS oncoprotein family.

Abstract

The beta factor, which interacts with the rpL32 promoter, binds to the sequence 5'-GAGCCGGAAGTG and trans-activates this gene. Comparison of the DNA sequences bound by the beta factor with those bound by other known DNA-binding proteins revealed that the ETS proteins interact with similar DNA sequences. Consequently we have examined the relationship of the beta factor to the several ETS proteins so far reported. Antibody and oligonucleotide competition experiments, performed by using electrophoretic shift analysis, revealed that the beta factor contains ETS epitopes and that it is immunologically related to both of the GA-binding proteins (GABPs), implying that the beta factor may consist of two separate protein subunits.

Entities: Chemical Gene

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Year: 1992 PMID： 1445193 PMCID： PMC1133171 DOI： 10.1042/bj2870349

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

41 in total

1. Enhanced cell-free transcription of the ribosomal protein L32 gene by the polyoma virus enhancer PEA3 DNA-binding protein.

Authors: T Yoganathan; A Cowie; J A Hassell; B H Sells
Journal: Eur J Biochem Date: 1992-07-01

2. A putative second cell-derived oncogene of the avian leukaemia retrovirus E26.

Authors: D Leprince; A Gegonne; J Coll; C de Taisne; A Schneeberger; C Lagrou; D Stehelin
Journal: Nature Date: 1983 Nov 24-30 Impact factor: 49.962

3. Expression of a beta-galactosidase gene containing the ribosomal protein 51 intron is sensitive to the rna2 mutation of yeast.

Authors: J L Teem; M Rosbash
Journal: Proc Natl Acad Sci U S A Date: 1983-07 Impact factor: 11.205

4. A comparison of yeast ribosomal protein gene DNA sequences.

Authors: J L Teem; N Abovich; N F Kaufer; W F Schwindinger; J R Warner; A Levy; J Woolford; R J Leer; M M van Raamsdonk-Duin; W H Mager
Journal: Nucleic Acids Res Date: 1984-11-26 Impact factor: 16.971

5. The gene family encoding the mouse ribosomal protein L32 contains a uniquely expressed intron-containing gene and an unmutated processed gene.

Authors: K P Dudov; R P Perry
Journal: Cell Date: 1984-06 Impact factor: 41.582

6. Primary structure of human ribosomal protein S14 and the gene that encodes it.

Authors: D D Rhoads; A Dixit; D J Roufa
Journal: Mol Cell Biol Date: 1986-08 Impact factor: 4.272

7. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.

Authors: J D Dignam; R M Lebovitz; R G Roeder
Journal: Nucleic Acids Res Date: 1983-03-11 Impact factor: 16.971

8. Tripartite structure of the avian erythroblastosis virus E26 transforming gene.

Authors: M F Nunn; P H Seeburg; C Moscovici; P H Duesberg
Journal: Nature Date: 1983 Nov 24-30 Impact factor: 49.962

9. Characterization of the expressed gene and several processed pseudogenes for the mouse ribosomal protein L30 gene family.

Authors: L M Wiedemann; R P Perry
Journal: Mol Cell Biol Date: 1984-11 Impact factor: 4.272

10. Nucleotide sequence of the L1 ribosomal protein gene of Xenopus laevis: remarkable sequence homology among introns.

Authors: F Loreni; I Ruberti; I Bozzoni; P Pierandrei-Amaldi; F Amaldi
Journal: EMBO J Date: 1985-12-16 Impact factor: 11.598

10 in total

1. hDREF regulates cell proliferation and expression of ribosomal protein genes.

Authors: Daisuke Yamashita; Yukako Sano; Yuka Adachi; Yuma Okamoto; Hirotaka Osada; Takashi Takahashi; Tomohiro Yamaguchi; Takashi Osumi; Fumiko Hirose
Journal: Mol Cell Biol Date: 2007-01-12 Impact factor: 4.272

2. A novel transcriptional initiator activity of the GABP factor binding ets sequence repeat from the murine cytochrome c oxidase Vb gene.

Authors: C Sucharov; A Basu; R S Carter; N G Avadhani
Journal: Gene Expr Date: 1995

3. Functional domains of transcription factor hGABP beta1/E4TF1-53 required for nuclear localization and transcription activation.

Authors: C Sawa; M Goto; F Suzuki; H Watanabe; J Sawada; H Handa
Journal: Nucleic Acids Res Date: 1996-12-15 Impact factor: 16.971

4. Comparative utilization of transcription factor GABP by the promoters of ribosomal protein genes rpL30 and rpL32.

Authors: R R Genuario; D E Kelley; R P Perry
Journal: Gene Expr Date: 1993

5. XrpFI, an amphibian transcription factor composed of multiple polypeptides immunologically related to the GA-binding protein alpha and beta subunits, is differentially expressed during Xenopus laevis development.

Authors: M Marchioni; S Morabito; A L Salvati; E Beccari; F Carnevali
Journal: Mol Cell Biol Date: 1993-10 Impact factor: 4.272

6. Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes.

Authors: A R Zinn; R K Alagappan; L G Brown; I Wool; D C Page
Journal: Mol Cell Biol Date: 1994-04 Impact factor: 4.272

7. Placing the RPL32 Promoter Upstream of a Second Promoter Results in a Strongly Increased Number of Stably Transfected Mammalian Cell Lines That Display High Protein Expression Levels.

Authors: F Hoeksema; K Hamer; M Siep; J A Verhees; A P Otte
Journal: Biotechnol Res Int Date: 2010-12-19