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Literature DB >> 1444335

The genetics of nuclear pre-mRNA splicing: a complex story.

Abstract

The occurrence of introns in nuclear precursor RNAs (pre-mRNAs) is widespread in eukaryotes, and the splicing process that removes them is basically the same in yeasts as it is in higher eukaryotes. Splicing takes place in a very large, multi-component complex, the splicesome, and biochemical studies have been complicated by the large number of splicing factors involved. This review describes how genetic approaches used to study RNA splicing in Saccharomyces cerevisiae have complemented the biochemical studies and led to rapid advances in the field.

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Year: 1992 PMID： 1444335 DOI： 10.1007/bf00584461

Source DB: PubMed Journal: Antonie Van Leeuwenhoek ISSN： 0003-6072 Impact factor: 2.271

62 in total

1. Meiosis-specific RNA splicing in yeast.

Authors: J A Engebrecht; K Voelkel-Meiman; G S Roeder
Journal: Cell Date: 1991-09-20 Impact factor: 41.582

2. Requirement of the RNA helicase-like protein PRP22 for release of messenger RNA from spliceosomes.

Authors: M Company; J Arenas; J Abelson
Journal: Nature Date: 1991-02-07 Impact factor: 49.962

3. Pseudogenes in yeast?

Authors: G R Fink
Journal: Cell Date: 1987-04-10 Impact factor: 41.582

4. Splicing of messenger RNA precursors.

Authors: P A Sharp
Journal: Science Date: 1987-02-13 Impact factor: 47.728

5. A quantitative analysis of the effects of 5' junction and TACTAAC box mutants and mutant combinations on yeast mRNA splicing.

Authors: A Jacquier; J R Rodriguez; M Rosbash
Journal: Cell Date: 1985-12 Impact factor: 41.582

6. A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family.

Authors: E J Strauss; C Guthrie
Journal: Genes Dev Date: 1991-04 Impact factor: 11.361

7. Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA.

Authors: R Parker; P G Siliciano; C Guthrie
Journal: Cell Date: 1987-04-24 Impact factor: 41.582

8. A trans-acting suppressor restores splicing of a yeast intron with a branch point mutation.

Authors: J R Couto; J Tamm; R Parker; C Guthrie
Journal: Genes Dev Date: 1987-07 Impact factor: 11.361

9. A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5' cleavage site.

Authors: B Séraphin; L Kretzner; M Rosbash
Journal: EMBO J Date: 1988-08 Impact factor: 11.598

The genetics of nuclear pre-mRNA splicing: a complex story.

1. Meiosis-specific RNA splicing in yeast.

2. Requirement of the RNA helicase-like protein PRP22 for release of messenger RNA from spliceosomes.

3. Pseudogenes in yeast?

4. Splicing of messenger RNA precursors.

5. A quantitative analysis of the effects of 5' junction and TACTAAC box mutants and mutant combinations on yeast mRNA splicing.

6. A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family.

7. Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA.

8. A trans-acting suppressor restores splicing of a yeast intron with a branch point mutation.

9. A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5' cleavage site.

10. The yeast MATa1 gene contains two introns.

Review 1. Yeast protein splicing factors involved in nuclear pre-mRNA splicing.

2. Optimization of SMN trans-splicing through the analysis of SMN introns.

3. Rds3p is required for stable U2 snRNP recruitment to the splicing apparatus.

4. Fission yeast gene structure and recognition.

5. The Saccharomyces cerevisiae PRP21 gene product is an integral component of the prespliceosome.