Literature DB >> 14342524

THE INHIBITION OF NICOTINAMIDE-ADENINE DINUCLEOTIDE-LINKED 3-ALPHA-HYDROXY STEROID DEHYDROGENASE BY CERTAIN ANTIMETABOLIC DRUGS.

R F LAMBE, D C WILLIAMS.   

Abstract

1. The inhibition of NAD-linked 3alpha-hydroxy steroid dehydrogenase in vitro by some of the more therapeutically effective antimetabolic drugs has been investigated. 2. Antipurine and antifolic acid drugs inhibit this system, as does folic acid. 3. Combinations of antifolic acid drugs and folic acid itself produce an additive but not synergic inhibition. 4. Antimetabolic drugs give inhibitions that are additive to those produced by antagonistic steroid hormones.

Entities:  

Keywords:  AMINOPTERIN; ANTIMETABOLITES; AZAURACIL; DIETHYLSTILBESTROL; ENZYME INHIBITORS; ESTRADIOL; EXPERIMENTAL LAB STUDY; FOLIC ACID; HYDROGEN-ION CONCENTRATION; HYDROXYSTEROID DEHYDROGENASE; MERCAPTOPURINE; METHOTREXATE; NAD; TESTOSTERONE

Mesh：

Substances：

Year:  1965        PMID： 14342524      PMCID： PMC1206815          DOI： 10.1042/bj0950847

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  10 in total

1.  Separation of human placental estrogen-sensitive transhydrogenase from estradiol-17 beta dehydrogenase.

Authors:  D D HAGERMAN; C A VILLEE
Journal:  J Biol Chem       Date:  1959-08       Impact factor: 5.157

2.  INHIBITION OF ALCOHOL DEHYDROGENASE BY FOLIC ACID AND SEVERAL OF ITS ANALOGS.

Authors:  W H VOGEL; R SNYDER; M P SCHULMAN
Journal:  Proc Soc Exp Biol Med       Date:  1964-02

3.  Reversible enzymatic oxidation of bile acids.

Authors:  O HAYAISHI; Y SATO; W B JAKOBY; E F STOHLMAN
Journal:  Arch Biochem Biophys       Date:  1955-06       Impact factor: 4.013

4.  The metabolism of tritiated folic acid in man.

Authors:  D G JOHNS; S SPERTI; A S BURGEN
Journal:  J Clin Invest       Date:  1961-09       Impact factor: 14.808

5.  Effect of 4-amino folic acid antagonists on biological acetylations.

Authors:  W JOHNSON; G CORTE; R JASMIN
Journal:  Proc Soc Exp Biol Med       Date:  1958-12

6.  Further studies on the phenylalanine-hydroxylation cofactor.

Authors:  S KAUFMAN; B LEVENBERG
Journal:  J Biol Chem       Date:  1959-10       Impact factor: 5.157

7.  A mammalian 3alpha-hydroxysteroid dehydrogenase.

Authors:  G M TOMKINS
Journal:  J Biol Chem       Date:  1956-01       Impact factor: 5.157

8.  The employment of combinations of drugs in the chemotherapy of neoplasia: a review.

Authors:  A GOLDIN; N MANTEL
Journal:  Cancer Res       Date:  1957-08       Impact factor: 12.701

9.  The inhibition of 3-alpha-hydroxy steroid-activated nicotinamide-adenine dinucleotide (phosphate) transhydrogenase by some antimetabolic compounds.

Authors:  P M Frearson; D C Williams
Journal:  Biochem J       Date:  1964-04       Impact factor: 3.857

10.  THE INHIBITION OF TWO STEROID-ACTIVATED NICOTINAMIDE-ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASES BY FOLIC ACID AND FOLIC ACID ANTIMETABOLITES.

Authors:  W I MAINWARING; D C WILLIAMS
Journal:  Biochem J       Date:  1965-03       Impact factor: 3.857
  10 in total
  3 in total

1.  Human cadaveric renal transplantation. Report of twenty cases.

Authors:  J F Mowbray; S L Cohen; P B Doak; J R Kenyon; K Owen; A Percival; K A Porter; W S Peart
Journal:  Br Med J       Date:  1965-12-11

2.  The enzymic reduction of nicotinamide-adenine dinucleotide by 2-mercaptoethanol.

Authors:  R F Lambe; D C Williams
Journal:  Biochem J       Date:  1965-11       Impact factor: 3.857

3.  Assessment of testicular testosterone production and Leydig cell structure.

Authors:  L L Ewing; B R Zirkin; C Chubb
Journal:  Environ Health Perspect       Date:  1981-04       Impact factor: 9.031
  3 in total

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