Literature DB >> 14340071

THE INHIBITION OF TWO STEROID-ACTIVATED NICOTINAMIDE-ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASES BY FOLIC ACID AND FOLIC ACID ANTIMETABOLITES.

W I MAINWARING, D C WILLIAMS.   

Abstract

1. It was found that steroid-mediated nicotinamide-adenine dinucleotide (phosphate) transhydrogenases can be inhibited in vitro by folic acid and its antimetabolites. The most potent inhibitor was methotrexate, a drug with a high therapeutic index against experimental cancer. 2. The inhibitions produced by a combination of folic acid and the analogues were additive, as were those between the folic acid compounds and antagonistic steroid hormones.

Entities:  

Keywords:  AMINOPTERIN; ANDROSTERONE; ENZYME INHIBITORS; ESTRADIOL; EXPERIMENTAL LAB STUDY; FOLIC ACID; HYDROGEN-ION CONCENTRATION; METHOTREXATE; NAD; NADP; OXIDOREDUCTASES; PHARMACOLOGY; PROGESTERONE; SPECTROPHOTOMETRY; TESTOSTERONE

Mesh：

Substances：

Year:  1965        PMID： 14340071      PMCID： PMC1206616          DOI： 10.1042/bj0940773

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  14 in total

1.  EARLY ESTROGEN EFFECTS ON NEWLY SYNTHESIZED RNA AND PHOSPHOLIPID IN SUBCELLULAR FRACTIONS OF RAT UTERI.

Authors:  J GORSKI; J A NICOLETTE
Journal:  Arch Biochem Biophys       Date:  1963-12       Impact factor: 4.013

2.  ON THE MECHANISM OF ACTION OF ALDOSTERONE ON SODIUM TRANSPORT: THE ROLE OF PROTEIN SYNTHESIS.

Authors:  I S EDELMAN; R BOGOROCH; G A PORTER
Journal:  Proc Natl Acad Sci U S A       Date:  1963-12       Impact factor: 11.205

3.  Purification and properties of the 3alpha-hydroxy steroid-dependent nicotinamide-adenine dinucleotide transhydrogenase of rat liver.

Authors:  D N BARON; M B GORE; R PIETRUSZKO; D C WILLIAMS
Journal:  Biochem J       Date:  1963-07       Impact factor: 3.857

4.  An effect of testosterone on amino acid incorporation by prostatic ribonucleoprotein particles.

Authors:  S LIAO; H G WILLIAMS-ASHMAN
Journal:  Proc Natl Acad Sci U S A       Date:  1962-11-15       Impact factor: 11.205

5.  Incorporation of ribonucleoside triphosphates into ribonucleic acid by nuclei of the prostate gland.

Authors:  R L HANCOCK; R F ZELIS; M SHAW; H G WILLIAMS-ASHMAN
Journal:  Biochim Biophys Acta       Date:  1962-01-22

6.  Relationship of 3 alpha-hydroxysteroid dehydrogenase to pyridine nucleotide transhydrogenases.

Authors:  A M STEIN; N O KAPLAN
Journal:  Science       Date:  1959-06-12       Impact factor: 47.728

7.  Studies on the mechanism of action of estrogens.

Authors:  G C MUELLER; A M HERRANEN; K F JERVELL
Journal:  Recent Prog Horm Res       Date:  1958

8.  Estradiol-sensitive isocitric dehydrogenase in noncancerous and cancerous human breast tissue.

Authors:  V P HOLLANDER; H JONAS; D E SMITH
Journal:  Cancer       Date:  1958 Jul-Aug       Impact factor: 6.860

9.  CONTROL OF GLUCOSE OXIDATION IN ANTERIOR PITUITARY BY HORMONALLY SENSITIVE PYRIDINE NUCLEOTIDE TRANSHYDROGENASE.

Authors:  J McGuire; L Pesch
Journal:  Proc Natl Acad Sci U S A       Date:  1962-12       Impact factor: 11.205

10.  The inhibition of 3-alpha-hydroxy steroid-activated nicotinamide-adenine dinucleotide (phosphate) transhydrogenase by some antimetabolic compounds.

Authors:  P M Frearson; D C Williams
Journal:  Biochem J       Date:  1964-04       Impact factor: 3.857
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  1 in total

1.  THE INHIBITION OF NICOTINAMIDE-ADENINE DINUCLEOTIDE-LINKED 3-ALPHA-HYDROXY STEROID DEHYDROGENASE BY CERTAIN ANTIMETABOLIC DRUGS.

Authors:  R F LAMBE; D C WILLIAMS
Journal:  Biochem J       Date:  1965-06       Impact factor: 3.857
  1 in total

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