Literature DB >> 14342236

PHOSPHATIDIC ACID SYNTHESIS IN YEAST.

N J KUHN, F LYNEN.   

Abstract

1. The presence of palmitoyl-CoA-l-glycerol 1-phosphate palmitoyltransferase (EC2.3.1.15) has been demonstrated in a particulate fraction of baker's yeast. 2. The enzyme has been characterized, and its activity studied as a function of pH and concentration of substrates. 3. Inhibition by thiol poisons and protection by acyl-CoA have been used to obtain information on the active site. 4. By various methods of supplying acyl radicals, the species ;palmitoyl-CoA' has been shown to be the true acyl donor to the transferase.

Entities:  

Keywords:  ACYLTRANSFERASES; AMIDES; CATALYSIS; CHROMATOGRAPHY; COENZYME A; ENZYME INHIBITORS; ETHYLMALEIMIDE; EXPERIMENTAL LAB STUDY; GLYCEROPHOSPHATES; HYDROGEN-ION CONCENTRATION; LIGASES; OLEIC ACID; PALMITIC ACID; PHARMACOLOGY; PHOSPHOLIPID METABOLISM; PYRROLES; SACCHAROMYCES

Mesh:

Substances:

Year:  1965        PMID: 14342236      PMCID: PMC1206433          DOI: 10.1042/bj0940240

Source DB:  PubMed          Journal:  Biochem J        ISSN: 0264-6021            Impact factor:   3.857


  18 in total

1.  Direct esterification of monoglycerides with palmityl coenzyme A by intestinal epithelial subcellular fractions.

Authors:  J R SENIOR; K J ISSELBACHER
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Journal:  Biochem Z       Date:  1962

3.  The identification of lysophosphatidylinositol and its enzymic conversion to phosphatidylinositol.

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Journal:  Biochim Biophys Acta       Date:  1962-07-02

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Journal:  Biochem Z       Date:  1957

5.  The structure of the naturally occurring phosphoglycerides. 4. Action of cabbage-leaf phospholipase D on ovolecithin and related substances.

Authors:  F M DAVIDSON; C LONG
Journal:  Biochem J       Date:  1958-07       Impact factor: 3.857

6.  Hydrolysis of lecithin by plant plastid enzymes.

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Journal:  Can J Biochem Physiol       Date:  1955-07

7.  Enzymatic synthesis of the coenzyme A derivatives of long chain fatty acids.

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Journal:  J Biol Chem       Date:  1953-09       Impact factor: 5.157

8.  Enzymatic esterification of alpha-glycerophosphate by long chain fatty acids.

Authors:  A KORNBERG; W E PRICER
Journal:  J Biol Chem       Date:  1953-09       Impact factor: 5.157

9.  A simplified purification of lecithin.

Authors:  M C PANGBORN
Journal:  J Biol Chem       Date:  1951-02       Impact factor: 5.157

10.  A rapid and simple method for the determination of esterified fatty acids and for total fatty acids in blood.

Authors:  I STERN; B SHAPIRO
Journal:  J Clin Pathol       Date:  1953-05       Impact factor: 3.411

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  10 in total

1.  Glycerolipid biosynthesis in Saccharomyces cerevisiae: sn-glycerol-3-phosphate and dihydroxyacetone phosphate acyltransferase activities.

Authors:  D M Schlossman; R M Bell
Journal:  J Bacteriol       Date:  1978-03       Impact factor: 3.490

2.  Gas liquid chromatographic analysis of sphingosine bases in sphingolipids of human normal and multiple sclerosis cerebral white matter.

Authors:  E A Moscatelli; E Isaacson
Journal:  Lipids       Date:  1969-11       Impact factor: 1.880

3.  The biosynthesis of dihydrosphingosine in cell-free preparations of Hansenula ciferri.

Authors:  P E Braun; E E Snell
Journal:  Proc Natl Acad Sci U S A       Date:  1967-07       Impact factor: 11.205

4.  Properties of glycerol phosphate acyl transferase from pigeon liver particles.

Authors:  D R Husbands; W E Lands
Journal:  Biochem J       Date:  1968-12       Impact factor: 3.857

5.  Studies on the formation of the prothrombin-converting complex.

Authors:  F Jobin; M P Esnouf
Journal:  Biochem J       Date:  1967-03       Impact factor: 3.857

6.  The nature of the stimulatory role of the supernatant fraction on triglyceride synthesis by the alpha-Glycerophosphate pathway.

Authors:  J M Johnston; G A Rao; P A Lowe; B E Schwarz
Journal:  Lipids       Date:  1967-01       Impact factor: 1.880

7.  14: Sphingosine, a novel sphingosine base from Procambarus clarkii.

Authors:  E A Moscatelli; K M Gilliland
Journal:  Lipids       Date:  1969-05       Impact factor: 1.880

8.  Phosphatidate biosynthesis in mitochondrial subfractions of rat liver.

Authors:  E H Shephard; G Hübscher
Journal:  Biochem J       Date:  1969-06       Impact factor: 3.857

9.  Phosphatidic acid and phosphatidylinositol metabolism in Schizosaccharomyces pombe.

Authors:  G L White; J N Hawthorne
Journal:  Biochem J       Date:  1970-04       Impact factor: 3.857

10.  Esterification of glycerol 3-phosphate in lactating guinea-pig mammary gland.

Authors:  N J Kuhn
Journal:  Biochem J       Date:  1967-10       Impact factor: 3.857

  10 in total

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