Literature DB >> 1433530

Processing and localization of Dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5.

L Zhang1, P M Mohan, R Padmanabhan.   

Abstract

Processing of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5 could be mediated by the catalytically active NS3 protease domain and NS2B in trans at the dibasic sites NS3-NS4A and NS4B-NS5. Subcellular localization of the unprocessed precursor NS3-NS4A-NS4B-NS5 showed that it was confined to a distinct subcellular organelle in the cytoplasm, which was distinct from the distribution of the mature NS5.

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Year:  1992        PMID： 1433530      PMCID： PMC240467     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  26 in total

1.  Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins.

Authors:  B Falgout; M Pethel; Y M Zhang; C J Lai
Journal:  J Virol       Date:  1991-05       Impact factor: 5.103

2.  Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase.

Authors:  T R Fuerst; E G Niles; F W Studier; B Moss
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

Review 3.  Flavivirus genome organization, expression, and replication.

Authors:  T J Chambers; C S Hahn; R Galler; C M Rice
Journal:  Annu Rev Microbiol       Date:  1990       Impact factor: 15.500

Review 4.  Flavivirus replication strategy.

Authors:  E G Westaway
Journal:  Adv Virus Res       Date:  1987       Impact factor: 9.937

5.  Production of yellow fever virus proteins in infected cells: identification of discrete polyprotein species and analysis of cleavage kinetics using region-specific polyclonal antisera.

Authors:  T J Chambers; D W McCourt; C M Rice
Journal:  Virology       Date:  1990-07       Impact factor: 3.616

6.  Sequence analysis of cloned dengue virus type 2 genome (New Guinea-C strain).

Authors:  K Irie; P M Mohan; Y Sasaguri; R Putnak; R Padmanabhan
Journal:  Gene       Date:  1989-02-20       Impact factor: 3.688

7.  Dissociation of NS5 from cell fractions containing West Nile virus-specific polymerase activity.

Authors:  J B Grun; M A Brinton
Journal:  J Virol       Date:  1987-11       Impact factor: 5.103

8.  Polymerase chain reaction-based point mutagenesis protocol.

Authors:  L J Zhao; Q X Zhang; R Padmanabhan
Journal:  Methods Enzymol       Date:  1993       Impact factor: 1.600

9.  Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease.

Authors:  A Cahour; B Falgout; C J Lai
Journal:  J Virol       Date:  1992-03       Impact factor: 5.103

10.  Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes.

Authors:  A E Gorbalenya; E V Koonin; A P Donchenko; V M Blinov
Journal:  Nucleic Acids Res       Date:  1989-06-26       Impact factor: 16.971
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  41 in total

1.  Structural and functional parameters of the flaviviral protease: a promising antiviral drug target.

Authors:  Sergey A Shiryaev; Alex Y Strongin
Journal:  Future Virol       Date:  2010-09-01       Impact factor: 1.831

Review 2.  Biochemistry and Molecular Biology of Flaviviruses.

Authors:  Nicholas J Barrows; Rafael K Campos; Kuo-Chieh Liao; K Reddisiva Prasanth; Ruben Soto-Acosta; Shih-Chia Yeh; Geraldine Schott-Lerner; Julien Pompon; October M Sessions; Shelton S Bradrick; Mariano A Garcia-Blanco
Journal:  Chem Rev       Date:  2018-04-13       Impact factor: 60.622

Review 3.  Molecular targets for flavivirus drug discovery.

Authors:  Aruna Sampath; R Padmanabhan
Journal:  Antiviral Res       Date:  2008-09-15       Impact factor: 5.970

Review 4.  Elucidating the role of T cells in protection against and pathogenesis of dengue virus infections.

Authors:  Anuja Mathew; Elizabeth Townsley; Francis A Ennis
Journal:  Future Microbiol       Date:  2014       Impact factor: 3.165

5.  Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus.

Authors:  M Hijikata; H Mizushima; Y Tanji; Y Komoda; Y Hirowatari; T Akagi; N Kato; K Kimura; K Shimotohno
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-15       Impact factor: 11.205

6.  Dynamics and binding interactions of peptide inhibitors of dengue virus entry.

Authors:  Diyana Mohd Isa; Sek Peng Chin; Wei Lim Chong; Sharifuddin M Zain; Noorsaadah Abd Rahman; Vannajan Sanghiran Lee
Journal:  J Biol Phys       Date:  2019-01-24       Impact factor: 1.365

7.  Context-Dependent Cleavage of the Capsid Protein by the West Nile Virus Protease Modulates the Efficiency of Virus Assembly.

Authors:  Laura A VanBlargan; Kaitlin A Davis; Kimberly A Dowd; David L Akey; Janet L Smith; Theodore C Pierson
Journal:  J Virol       Date:  2015-06-10       Impact factor: 5.103

8.  NS3 is a serine protease required for processing of hepatitis C virus polyprotein.

Authors:  L Tomei; C Failla; E Santolini; R De Francesco; N La Monica
Journal:  J Virol       Date:  1993-07       Impact factor: 5.103

9.  NS2B-3 proteinase-mediated processing in the yellow fever virus structural region: in vitro and in vivo studies.

Authors:  S M Amberg; A Nestorowicz; D W McCourt; C M Rice
Journal:  J Virol       Date:  1994-06       Impact factor: 5.103

10.  The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replication.

Authors:  Moon Y F Tay; Wuan Geok Saw; Yongqian Zhao; Kitti W K Chan; Daljit Singh; Yuwen Chong; Jade K Forwood; Eng Eong Ooi; Gerhard Grüber; Julien Lescar; Dahai Luo; Subhash G Vasudevan
Journal:  J Biol Chem       Date:  2014-12-08       Impact factor: 5.157
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