| Literature DB >> 1433273 |
M L Marthas1, C J Miller, S Sutjipto, J Higgins, J Torten, B L Lohman, R E Unger, R A Ramos, H Kiyono, J R McGhee.
Abstract
The ability of two vaccine preparations (UV-psoralen inactivated SIV administered intramuscularly and live-attenuated SIV inoculated intravaginally) to prevent genital transmission of virulent SIV in rhesus macaques was tested. Two of six whole-inactivated SIV vaccinated macaques, three of five live-attenuated SIV vaccinated macaques, and four of six controls became persistently infected after two separate intravaginal inoculations with a 50% animal infectious dose of virulent SIV. No association was observed between levels of SIV-specific antibodies in serum or vaginal secretions prior to challenge and subsequent infection with virulent SIV.Entities:
Mesh：
Substances：
Year: 1992 PMID： 1433273
Source DB: PubMed Journal: J Med Primatol ISSN： 0047-2565 Impact factor: 0.667